L-脯氨甲酰基二茂铁的合成及表征  

Synthesis and Characterization of L-prinoylferrocene

作　　者：黄建康[1] 哈伍族[1] 张铁江[1] 黄继明[1] 

机构地区：[1]武汉纺织大学化学与化工学院,湖北武汉430200

出　　处：《广东化工》2012年第17期22-22,11,共2页Guangdong Chemical Industry

摘　　要：以L-脯氨酸为手性源,经亚氨基保护,酰氯化,Friedel-Crafts酰基化,去保护四步,最终合成了L-脯氨甲酰基二茂铁,一种手性有机小分子化合物。其结构经IR、1HNMR表征。在第三步付克酰基化反应中,以二氯甲烷为溶剂,氧化锌作为路易斯酸催化剂,收率达到43%,使用氧化锌代替三氯化铝对环境保护有积极作用。L-Prinoylferrocene which is a small molecule were synthesized in for steps from L-proline and ferrocene through the reaction sequence of protection, acyl chlorination, Friedel-Crafts acylation, remove protecting group. The structures were characterized by means of IR and I H-NMR. Third step was Friedel-crafls acylation reaction, dichloromethane as solvent, zinc oxide was select as lewis acid catalyst, compare with aluminium trichloride which was environmental Friendly, and the yield reached 43 %.

关 键 词：有机合成 二茂铁 L-脯氨酸 

分 类 号：TQ464.7[化学工程—制药化工]