琥珀酰化壳聚糖-铜(Ⅱ)-苯并咪唑衍生物配合物的合成、表征及抗菌活性  

Synthesis Characterization and Antibacterial Activities of Copper(II) Complexes with Succinyl-Chitosan and Benzimidazole Derivatives

作　　者：王彩霞[1] 黄跃龙[1] 陈佳阳[1] 乐学义[1] 

机构地区：[1]华南农业大学理学院应用化学系,广东广州510642

出　　处：《广东化工》2012年第18期3-5,共3页Guangdong Chemical Industry

基　　金：广东省科技计划项目(2011B020310005);华南农业大学211工程项目(2009B010100001)

摘　　要：文章利用琥珀酸酐对壳聚糖进行改性,并合成了两个新的配合物:sucts-Cu(Ⅱ)-hpb(1)和sucts-Cu(Ⅱ)-tbz(2)[sucts=琥珀酰化壳聚糖,hpb=2-(2’-吡啶)-苯并咪唑,tbz=2-(4′-噻唑基)苯并咪唑]。应用红外光谱,紫外-可见光谱,原子吸收光谱对配合物进行了表征,采用试管倍比稀释法研究了这些配合物对苏云金杆菌、枯草芽孢杆菌、大肠杆菌和金黄色葡萄球菌的抑制作用。结果表明,两种配合物对四种细菌均有较强的抑菌活性,配合物1、2,最小抑菌浓度(MIC)分别为62.5～125μg.mL-1和125～250μg.mL-1,抗菌效果明显强于自由配体。Chitosan was modified by the way of succinic anhydride and two new copper（ II ） complexes： sucts-Cu（ II ）- hpb（1） and sucts-Cu（ II ）-tbz（2）, where sucts, hpb and tbz are the succinyl-chitosan, 2-（2＇-pyridyl） benzimidazole and 2-（4＇-thiazolyl）benzimidazole, respectively, were synthesized and characterized by infrared absorption spectrum, electronic absorption spectrum and atomic absorption spectrometry. The complexes were tested for their ability to inhibit the growth of B. Thuringiensis（G-）, B. Subtilis（G＋）, E. Co i （G-） and S. Aureus （G＋）. The results showed that the minimum inhibitory concentrations of complexes 1 and 2 were 62.5-125 μg.mL-1 and 125-250 μg.mL-1, respectively.

关 键 词：琥珀酸酰壳聚糖 铜(II)配合物 苯并咪唑衍生物 抗菌活性 

分 类 号：O626.23[理学—有机化学]