苯海拉明的拉曼光谱和红外光谱研究  

Infrared and Raman Spectra Studies of Diphenhydramine Hydrochloride

作　　者：王吉有[1] 郭姣[1] 邹兆贵[1] 孔乐[1] 段苹[1] 

机构地区：[1]北京工业大学应用数理学院,北京100022

出　　处：《光散射学报》2012年第4期371-374,共4页The Journal of Light Scattering

基　　金：北京市教委人才强教计划(006000543111500);国家基金(10804005)

摘　　要：测量并分析了盐酸苯海拉明的红外光谱和拉曼光谱。在Raman光谱中,1001cm-1出现一个极强峰,在1030cm-1和618cm-1各有一个中等峰,此外,在红外光谱中,714cm-1和757cm-1附近出现极强的吸收峰,认定这个化合物中存在单取代苯。C-N的对称伸缩振动出现在837cm-1,1433cm-1和1470cm-1分别为CH2和CH3的变形振动,在红外光谱中,1020cm-1处明显的吸收峰属于C-O-C反对称伸缩振动。此外,测量得到含量为25mg苯海拉明药片的拉曼光谱与纯苯海拉明的拉曼峰比较一致,可作为无损快速检测该药物的手段。Abstract ： The Raman spectra and FT-infrared spectra of polycrystalline samples of diphen- hydramine hydrochloride are measured and analyzed. The Raman band at 1001 cm-1 and 1030 cm-1 were ascribed to breathing in ring and CH wagging vibration in monosubstituted Benzene. The deformation vibration of CH2 and CH3 are observed at 1433 and 1470 cm-1 , the stretching vibration of C--N 837 cm-1. The bands at 1020 cm-1 are due to C--O--C asymmetric symmetric stretching vibration. In addition, the Raman Spectroscopy of the diphenhydramine hydrochloride tablet was measured. Employing their similar characteris- tic peaks, these spectra can be applied to the non-destructive and rapid determination of di- phenhydramine hydrochloride tablet.

关 键 词：拉曼光谱 红外光谱 盐酸苯海拉明 

分 类 号：O657.37[理学—分析化学]