支气管哮喘患者血清半乳凝素-7水平的临床研究  

Clinical Research on Levels of Galectin-7 in Serum in Patients with Bronchial Asthma

作　　者：孙丽华[1] 张静[1] 毛山[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)呼吸科,南京210006

出　　处：《临床误诊误治》2012年第12期29-31,共3页Clinical Misdiagnosis & Mistherapy

基　　金：国家自然科学基金(81100010)

摘　　要：目的探讨支气管哮喘(哮喘)患者血清半乳凝素-7水平检测的意义。方法选取哮喘急性发作期患者25例为哮喘组,经治疗后上述患者进入临床缓解期,选取同时期23例健康者为对照组。测定所有研究对象血清半乳凝素-7水平及肺功能指标1秒用力呼气容积百分比(FEV1%)并进行对比。结果哮喘组急性发作期及缓解期血清半乳凝素-7水平均高于对照组,差异有统计学意义(P<0.01),哮喘组急性发作期血清半乳凝素-7水平高于缓解期,差异亦有统计学意义(P<0.01)。哮喘患者急性发作期血清半乳凝素-7水平与FEV1%呈负相关(r=-0.9544,P<0.05),与病程呈正相关(r=0.9290,P<0.05)。结论半乳凝素-7积极参与哮喘的发病,可以作为评价哮喘临床治疗效果的检测指标之一。Objective To investigate the clinical significance of Galectin-7 in the pathogenesis of bronchial asthma.Methods 25 patients with asthma in acute exacerbation period were enrolled as the experimental group.After treatment all the patients reached clinical remission stage.23 healthy people were enrolled as the control group.The levels of Galectin-7 in serum and forced expiratory volume percentage（FEV1%） of the two groups were measured and compared.Results The levels of Galectin-7 in serum were significantly higher in patients during acute exacerbation period and remission stage of asthma than that of the control group（P0.01）,and the levels of Galectin-7 in serum were higher in patients with acute exacerbation period than that of remission stage（P0.01）.The levels of Galectin-7 in serum were negatively correlated with FEV1% in the asthma exacerbation period（r=-0.9544,P0.05）,and the levels of Galectin-7 in serum were positively correlated with the course of the disease in the asthma exacerbation period（r=0.9290,P0.05）.Conclusion The phenomena of Galectin-7 actively involved in the pathogenesis of asthma may be one of the indexes to evaluate the clinical curative effect of asthma.

关 键 词：半乳凝素-7 气道上皮细胞 支气管哮喘 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]