孕期补充n-3长链多不饱和脂肪酸对婴儿出生头围影响的Meta分析  

Meta-analysis of effect of n-3 long-chain polyunsaturated fatty acid supplementation of pregnant women on head circumference of newborn infa]lts

作　　者：邓娟[1] 谢林[1] 刘国良[1] 杨镜玉[1] 

机构地区：[1]吉林大学公共卫生学院营养与食品卫生教研室,吉林长春130021

出　　处：《中华预防医学杂志》2012年第12期1112-1116,共5页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金（81102115）

摘　　要：目的探讨孕妇补充n．3长链多不饱和脂肪酸（n．3LC—PUFA）对婴儿出生头围的影响。方法以n．3长链多不饱和脂肪酸、孕妇、婴儿、头围、n-3、LC．PUFA、DHA、EPA、docosahexaenoic acid,eicosapentaenoic acid,fish oil,pregnancy,infant为检索词，分别检索PubMed数据库、Cochrane图书馆、中国期刊全文数据库、万方数据库，搜集研究孕妇摄取n-3、LC—PUFA与婴儿出生头围关联性的随机对照研究全文文献，并进行筛选。应用RevMan5．0软件对符合纳入标准的8篇文献进行分析，应用方差倒数法计算加权均数差，并对结果进行敏感性分析。结果共纳入8篇文献，全部为英文文献，其中6篇来自发达国家，2篇来自发展中国家。入选文献年限跨度为2001--2011年。干预组（补充n-3LC—PUFA）共有871名研究对象，对照组（不补充n-3、LC—PUFA或使用安慰剂）共有894名研究对象。孕妇补充n-3LC—PUFA对婴儿出生头围影响的加权均数差为0．17on，其95％C／值为（0．01—0．32）on，P〈0．05。进行敏感性分析后，加权均数差为0．16cm，95％C／值为（-0．01—0．34）em，P=0．07。合并结果漏斗图基本对称，纳入的文献不存在发表偏倚，具有较好的代表性。结论目前的资料尚不能确认孕期补充n-3LC—PUFA可增加婴儿的出生头围。Objective To evaluate systematically the effect of n-3 long-chain polyunsaturated fatty acid （n-3 LC-PUFA ） supplementation of pregnant women on head circumference of newborn infants. Methods A thorough literature search was done for full texts which studied the effect of n-3 LC-PUFA supplementation of pregnant women on head circumference of newborn infants among PubMed, Cochrane Library, Chinese periodical full text database and Wanfang database using the mesh terms as n-3, long chain polyunsaturated fatty acids, DHA, EPA, docosahexaenoic acid, eicosapentaenoic acid, fish oil, pregnancy,infant. Only randomized controlled trials were chosen for analysis. A total of 74 relevant articles were selected. RevMan 5.0 software was used to perform the Meta analysis on those valid studies. Weighted mean difference was calculated with inverse variance method. The sensitivity analysis was also performed. Results Eight articles met the inclusion criteria, among which 6 literatures were from developing countries and the other 2 from developed countries. All of them were written in English. These studies were reported fi＇om 2001 to 2011. Intervention group included 871 objects with n-3 LC-PUFA supplementation, whereas control group included 894 objects with placebo or no supplementation. Supplementation was associated with significantly greater head circumference of the infants in the intervention group than that of the control group （ weighted mean difference was 0. 17 cm, 95% confidence interval （CI） was 0. 01 - 0. 32 cm, P 〈 0. 05 ）. But the difference was no long significant according to the sensitivity analysis （ weighted mean difference was 0. 16 cm,95% CI was -0. 01 -0. 34 cm,P =0. 07）. The funnel plot was symmetrical, indicating there was no publication bias between the eight studies. Conclusion It can＇t be confirmed whether supplementation with n-3 LC-PUFA of pregnant women can increase the infants＇ head circumference at birth from present data acquired.

关 键 词：META分析 婴儿 出生头围 孕期 n-3长链多不饱和脂肪酸 

分 类 号：R174[医药卫生—妇幼卫生保健]