检测核周型抗中性粒细胞胞浆抗体在溃疡性结肠炎中的意义  

作　　者：邱丽[1] 

机构地区：[1]湖北省襄阳市中心医院消化内科,441021

出　　处：《浙江临床医学》2012年第12期1471-1472,共2页Zhejiang Clinical Medical Journal

摘　　要：【摘要】目的探讨核周型抗中性粒细胞胞浆抗体（peri—nuclearanti—neutrophilcytoplasmicantibodies，pANCA）在溃疡性结肠炎中的临床意义。方法选择溃疡性结肠炎患者60例为研究对象，以正常健康人60例为对照，采用间接免疫荧光法检测pANCA，比较二者差异，并分析与临床病理因素的关系。结果溃疡性结肠炎患者pANCA阳性率68．3％，正常健康人1．7％，差异有统计学意义（P〈0．01）。pANCA对溃疡性结肠炎的诊断特异性92．7％，灵敏度65．9％。溃疡性结肠炎患者pANCA阳性率与性别、年龄和病变部位差异无统计学意义，与病程、病情严重程度差异有统计学意义（P〈0．05），病程越短、病情越严重，pANCA阳性率越高。结论pANCA诊断溃疡性结肠炎具有特异性强、灵敏度高优点，病程越短、病情越严重，pANCA阳性率越高。Objective To explore the clinical value of pANCA （peri-nuclear anti-neutrophil cytoplasmic antibodies） in the ulcerative colitis. Methods 60 cases of ulcerative colitis patients were investigated, 60 healthy people were used for control. ;Indirect immunofluorescence was applied for detection of pANCA, comparison was made between two groups and the relationship to clinical pathological factors were analyzed. Results The positive rate of pANCA was 68.3% in ulcerative colitis group while 1.7% in control group, the difference was significant （ P〈0.01 ） . The diagnostic specific rate ofpANCA for ulcerative colitis was 92.7%, with the sensitive rate of 65.9%. The positive rates were not significantly different among patients of different gender, age and lesion＇ s locations, but were significantly different among patients of different duration and severity of the disease （ P〈0.05 ） . The positive rate was higher in the patients with shorter duration and more severity of the disease. Conclusions The pANCA is specific and sensitive for diagosis of ulcerative colitis,its positive rate is higher in the patients with shorter duration and more severity of the disease.

关 键 词：溃疡性结肠炎核周型抗中性料细胞胞浆抗体特异性灵敏度 

分 类 号：R392.11[医药卫生—免疫学]