血浆脑钠肽与C反应蛋白在心力衰竭中的应用价值  

Application value of plasma B-type natriuretic peptide and C-reactive protein in cardia failure

作　　者：陈阳[1] 

机构地区：[1]靖江市人民医院心血管科,江苏靖江214500

出　　处：《江苏实用心电学杂志》2012年第4期251-253,255,共4页Journal of Practical Electrocardiology JS

摘　　要：目的探讨血浆B型脑钠肽(BNP)和C反应蛋白(CRP)对心力衰竭患者的应用价值,为临床实践提供参考。方法分别检测84例心力衰竭患者(观察组)和40例健康体检者(对照组)入院24h内血浆BNP和CRP的浓度,同时测定两组患者的左室舒张末期内径(LVED)和左室射血分数(LVEF),比较BNP和CRP与心力衰竭患者心功能指标变化之间的关系。结果观察组患者的BNP、CRP、LVED均显著增高(P<0.01),且随心功能分级的增高而增高;LVEF则明显降低(P<0.01),且心功能分级越高,LVEF越低。BNP与心功能分级、LVEF、LVED均有显著的相关性(P<0.05),而CRP只与心功能分级相关(P<0.05),与LVEF和LVED的相关性无统计学意义(P>0.05)。结论在诊断和评价心力衰竭中,BNP和CRP均可反应心力衰竭的严重程度,临床可检测这两者的水平,辅助超声心动图、心电图等检查,作为评价心功能的重要补充,但BNP的特异性优于CRP。Objective To study the application value of plasma B-type natriuretic peptide and C-reactive protein in eardia failure. Methods Eighty-four patients with cardia failure （observation group） and 40 health examination persons （control group） were enrolled in this study. Plasma levels of BNP and CRP were detected in 24 h after hospitalization, as well as left ventricular end-diastolic diameter （LVED） and left ventricular ejection fraction （LVEF）. Results Plasma levels of BNP, CRP and LVED of the observation group were higher than those of the control group （P 〈0.01 ） ,and compared to cardiac function grading, it was positive correlation, while LVEF decreased （P 〈 0.01 ）and it was negative correlation. It showed a significant correlation between BNP and cardiac function grading, LVEF, LVED （ P 〈 0.05 ）, whereas CRP related to cardiac function grading only （ P 〈 0.05 ）, There was no significant correlation between LVEF and LVED. Conclusion Both BNP and CRP may reflex the condition severity of heart failure. In clinical application, we could use the levels of BNP and CRP as an important supplement to evaluate cardiac function, but as to the specificity, BNP was better than CRP.

关 键 词：心力衰竭 B型脑钠肽 C反应蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]