他汀类药物预防房颤射频消融术后复发疗效评估的荟萃分析  

Use of Statins for Prevention of Atrial Fibrillation Recurrence after Catheter Ablation: a Meta-analysis

作　　者：王云帆[1] 陈鹏[2] 

机构地区：[1]浙江省人民医院,310014 [2]浙江大学医学院附属第一医院,310003

出　　处：《心脑血管病防治》2012年第6期455-458,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的用Meta分析的方法评价他汀类药物是否可有效预防房颤射频消融术后的复发。方法检索Pubmed和Embase等数据库,查找有关他汀类药物预防房颤射频消融术后复发的文献。用Revman软件进行Meta分析,比较他汀治疗组与对照组之间消融术后的房颤复发率。同时对C反应蛋白(CRP)等炎症指标进行组间比较。结果经检索与筛查后共纳入6篇文献,计1185名患者。Meta分析显示他汀组随访终点时房颤复发率与对照组比较差异无统计学意义。但他汀组的终点CRP水平显著低于对照组。两组间基线CRP水平比较差异无统计学意义。两组内消融术前后CRP水平比较差异无统计学意义。结论他汀类药物不能预防房颤射频消融术后的复发。Objective To evaluate the use of statins whether can prevent atrial fibrillation （AF） recurrence after catheter ablation. Methods We searched databases of Pubmed and Embase online for relative studies of using statins to prevent AF after catheter abla- tion. Data analysis was conducted using Revman. The AF recurrence rates after catheter ablation were compared between statins ther- apeutic group and the control group. Inflammation markers, such as C-reactive protein （CRP）, were also compared between the above mentioned groups. Results A total of 6 studies, which included 1185 patients, were enrolled into the meta-analysis. It was demonstrated that there was no significant difference in endpoint AF recurrence rates between the statins therapeutic group and the control group. The endpoint CRP levels in statins therapeutic group were significantly lower than those in control group. No significant differences were found in the comparison of baseline CRP levels between the two groups. There were also no significant differences in the comparison-ison of CRP levels between baseline and endpoint in either statins therapeutic group or control group, respectively. Con- dusions Use of statins cannot prevent AF recurrence after catheter ablation.

关 键 词：心房颤动 射频消融术 他汀 复发 预防 

分 类 号：R541.75[医药卫生—心血管疾病] R972[医药卫生—内科学]