硫酸镁配伍美托洛尔治疗急性心肌梗死后室性心律失常的临床研究  

Clinical research into magnesium sulfate combined with metoprolol in the treatment of acute myocardial infarction with ventricular arrhythmias

作　　者：何小萍[1] 

机构地区：[1]广东省东莞市人民医院心血管内科,523000

出　　处：《白求恩军医学院学报》2012年第6期457-459,共3页Journal of Bethune Military Medical College

摘　　要：目的探讨硫酸镁联合美托洛尔治疗急性心肌梗死后室性心律失常的临床效果。方法将急性心肌梗死后室性心律失常患者106例随机分为观察组和对照组,各53例。对照组采用利多卡因治疗,观察组采用硫酸镁联合美托洛尔治疗,对急性心肌梗死后3d内及4～30d室性心律失常发生次数及治疗前后的心功能指标进行分析比较。结果急性心肌梗死后3d内及4～30d观察组室性心律失常的发生率均低于对照组(P<0.01)。两组患者治疗后的左室射血分数(LVEF)、左室短轴缩短率(FS)、二尖瓣舒张早期与舒张晚期血流峰值速度比值(E/A)均较治疗前明显升高(P<0.01)。结论采用硫酸镁联合美托洛尔治疗可降低急性心肌梗死后室性心律失常的发生率,值得临床推广应用。Objective To investigate the clinical therapeutic effect of using magnesium sulfate combined with metoprolol to treat acute myocardial infarction with ventricular arrhythmias.Methods One hundred and six patients with ventricular arrhythmias after acute myocardial infarction were randomly divided into control group in which patients received dolicaine and observation group in which patients received magnesium sulfate combined with metoprolol.Three days after acute myocardial infarction and four to thirty days after acute myocardial infarction,the incidence of ventricular arrhythmias and indicators of cardiac function before and after treatment were compared.Results The incidence of ventricular arrhythmias of the patients in the observation group was obviously lower than that of the control group（P 0.01）.The LVEF,FS and E/A of the patients in both groups after treatment were significantly improved than that of before treatment（P 0.01）.Conclusion Treating acute myocardial infarction with ventricular arrhythmia with magnesium sulfate and metoprolol which can lower the incidence of ventricular arrhythmias is worth applying clinically.

关 键 词：急性心肌梗死 室性心律失常 硫酸镁 美托洛尔 

分 类 号：R541.7[医药卫生—心血管疾病]