新生儿巨细胞病毒感染与颅内损伤的关系  

The Analysis of the Relationship between Cytomegalovirus Infection and Intracranial Injury In Newborn

作　　者：谢月娥[1] 费淑兰[1] 周云[1] 史文元[1] 

机构地区：[1]郴州市第一人民医院儿童医院,湖南郴州423000

出　　处：《现代临床医学》2012年第6期419-421,共3页Journal of Modern Clinical Medicine

摘　　要：目的:探讨新生儿巨细胞病毒感染与颅内损伤关系。方法:回顾性分析我院464例巨细胞病毒感染新生儿临床资料。患儿分为CMV-IgM阳性组(IgM阳性组)、CMV-DNA阳性组(DNA阳性组)和CMV-IgM、CMV-DNA双阳性组(双阳性组),比较3组颅内损伤差异。结果:IgM阳性组与双阳性组颅内损伤发病率无显著性差异(P>0.05),且均高于DNA阳性组(P<0.01)。3组颅内出血发病率无显著性差异(P>0.05);谷丙转氨酶(ALT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均显著升高,组间比较无显著性差异(P>0.05)。结论:巨细胞病毒活动性感染更易造成新生儿颅内损伤。巨细胞病毒活动性感染与潜伏性感染对颅内出血的影响无显著差别。Objective： To analyze the relationship between cytomegalovirus infection and intracranial injury in newborn. Methods：Retrospectively analyzed the clinical datas of the 464 cases with cytomegalovirus in neonatal department. Divided the patients into three groups：IgM positive group, DNA positive group and double positive group. Compared the intracranial injury incidence among these groups. Results：The intracranial injury incidence was no significant difference between the IgM positive group and double positive group （P 〉0.05）. And the incidence of the two groups were higher than that of the DNA positive group（P 〈 0.01 ）. The brain hemorrhages incidence was no significant difference among three groups （ P 〉 0.05 ）. The glutamie - pyruvic transaminase（ALT）, protrombin time （FF） and activated partial thromboplastin time （AFFF） were increased in three groups, which was no significant difference among three groups （ P 〉 0.05 ）. Conclusions ： Cytomegalovirus active infection can cause the newborn intraeranial injury. And there is no significant difference between eytomegalovirus active infection and latent infection in the brain hemorrhages.

关 键 词：巨细胞病毒 活动性感染 颅内损伤 颅内出血 

分 类 号：R722.13[医药卫生—儿科]