药用库拉索芦荟活性多糖的护肤特性研究  

Skincare characteristic of active polysaccharide from Aloe vera

作　　者：任海毅[1] 王巧娥[1] 董银卯[1] 孟宏[2] 

机构地区：[1]北京工商大学理学院北京市植物资源研究开发重点实验室,北京100048 [2]中国中医科学院针灸研究所,北京100700

出　　处：《药物评价研究》2012年第6期431-434,共4页Drug Evaluation Research

基　　金：十二五科技支撑计划(2012BAD36B02);北京市优秀人才培养资助计划(2012D005003000008);北京市属高等学校科学技术与研究生教育创新工程建设项目(PXM2012_014213000068)

摘　　要：目的研究库拉索芦荟多糖的保湿特性、经皮吸收特性以及皮肤安全性。方法采用超声辅助提取芦荟活性多糖,并通过人体皮肤水分含量和水分散失量测试法对所制备的芦荟活性多糖的保湿特性(包括锁水、保水两个方面)进行评价;Franz扩散池体外透皮吸收法评价其透皮吸收特性;人体斑贴试验评价其皮肤安全性。结果与空白对照组比较,库拉索芦荟多糖可显著提高皮肤水合状态(P<0.05),同时降低经皮失水(P<0.05);多糖质量浓度为5%时,皮肤渗透速率达到0.2510mg/(h·cm2),24h累计渗透量达(4.1519±0.0462)mg/cm2;人体皮肤斑贴试验中全部评定为0级反应。结论库拉索芦荟活性多糖对皮肤具有显著的保湿功效以及较强的皮肤渗透力,并且高度安全,可作为优良的保湿添加剂在化妆品等肤用产品中广泛应用。Objective To investigate the moisturizing properties,percutaneous absorption,and skin safety of active polysaccharide from Aloe vera（APAV）.Methods The APAV was extracted from Aloe vera by the ultrasonic assisted extraction.The moisturizing property of the prepared sample was evaluated by the human skin moisture value determination and transepidermal water loss determination.The transdermal absorption characteristics of APAV was investigated by Franz diffusion cell in vitro transdermal absorption method.The skin safety was investigated by the human skin patch test method.Results APAV could significantly improve skin hydration status（P0.05）,as well as reduce the skin water loss（P0.05）.When the mass concentration of APAV was 5%,the skin penetration rate was 0.251 0mg/（h·cm2） and the quantity of the transdermal absorption was（4.151 9±0.046 2）mg/cm2 in 24h.The results of the human skin patch test were all in 0 level.Conclusion The results show that APAV has the significant moisturizing effect and strong penetration of the skin and high security on the human skin.It could be used as the moisturizing additive in cosmetic skin products.

关 键 词：库拉索芦荟 多糖 护肤功效 皮肤渗透 保湿 

分 类 号：R986[医药卫生—药品] TQ658.2[医药卫生—药学]