植物成分与细胞色素P450相互作用的研究进展  

Study on interaction between cytochrome P450 and phytochemicals

作　　者：孙敏[1,2] 刘鹏[2] 付晓丽[2] 徐为人[1,2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院天津市新药设计与发现重点实验室,天津300193

出　　处：《药物评价研究》2012年第6期465-468,共4页Drug Evaluation Research

基　　金：国家重大新药创制专项(2011ZX09401-009;2010ZX09401-307-1-1)

摘　　要：细胞色素P450(CYP450)是体内参与药物代谢的重要酶系,其活性在受到诱导或抑制后将干扰药物的作用。植物成分普遍存在于食物与药物中,与CYP450的相互作用将产生广泛影响。总结近年来植物成分与细胞色素P450的7个亚型CYP1A2、CYP2A6、CYP2C9、CYP2C19、CYP2D6、CYP2E1、CYP3A4相互作用的研究结果,为临床上合理用药提供参考。Cytochrome P450 is a kind of important enzyme for the metabolism of drugs and could interfere the effects of drugs after the activity is inhibited or induced.The phytochemicals are widespread in food and drugs,and have a lot of chances to interact with drugs on cytochrome P450.This kind of interaction has wide-ranging impacts.Therefore,this article reviews the interaction between phytochemicals and seven major isoforms of cytochrome P450（CYP1A2,CYP2A6,CYP2C9,CYP2C19,CYP2D6,CYP2E1,and CYP3A4） and provides the valuable information for the rational use of related medicines in clinic.

关 键 词：细胞色素P450 植物成分 相互作用 

分 类 号：R969.2[医药卫生—药理学]