两种不同四联疗法对Hp根除率影响的比较  

Comparing the impact of two different quadruple therapy against eradication rate of Hp

作　　者：许丽娟[1] 张中平[1] 陈育建[1] 葛亚强[1] 

机构地区：[1]江苏大学附属武进医院,江苏常州213102

出　　处：《中医临床研究》2012年第22期3-4,共2页Clinical Journal Of Chinese Medicine

摘　　要：背景:标准三联疗法对Hp的根除率逐渐下降,迫切需要在人群中选择新的治疗方案,本研究比较以铋剂为基础的四联疗法和以PPI为基础的四联疗法对Hp的影响。方法:收集了160例感染Hp的功能性消化不良的患者,随机分为两组:第一组(铋剂组):枸橼酸铋钾300mg,qid;奥美拉唑20mg,bid;四环素500mg,qid;阿莫西林1000mg,bid。第二组(非铋剂组):奥美拉20mg,bid;四环素500mg,qid;阿莫西林1000mg,bid;替硝唑500mg,bid。结果:共有152例患者完成疗程,铋剂组按实际处理分析(ITT)及按方案处理分析(PP)Hp的根除率分别为88.0%、85.0%,非铋剂组按实际处理分析(ITT)及按方案处理分析(PP)Hp的根除率分别为80.5%、77.5%。铋剂组Hp的根除率较非铋剂组高,但二者的差异无统计学意义,共有8例患者由于副作用未完成疗程(铋剂组3例,非铋剂组5例)。结论:以铋剂为基础的四联疗法和以PPI为基础的四联疗法对Hp的根除达到了中等度的根除率,同时,患者的耐受性亦对Hp的根除率有影响。Background：The standard triple therapy for the eradication rate of Hp gradually decreased,an urgent need for new treatment options in the crowd,this study compared the bismuth-based quadruple therapy and PPI-based quadruple therapy on Hp.Methods：160 cases of Hp infection in patients with functional dyspepsia were randomly divided into two groups：First group（bismuth group）：Bismuth potassium citrate 300mg,qid;omeprazole 20mg,bid;tetracycline 500mg qid;amoxicillin 1000mg,bid.The second group（non-bismuth group）：Omeprazole 20mg twice daily;tetracycline 500mg qid;amoxicillin 1000mg,bid;tinidazole 500mg,bid.Results：A total of 152 patients completed the treatment,according to the actual processing and analysis（ITT） and program processing and analysis（PP）,Hp eradication rates of bismuth group were 88.0%,85.0%,and were 80.5% and 77.5% of the non-bismuth group.The Hp eradication rate of the bismuth group was higher than that of the non-bismuth group,but the difference was not statistically significant,a total of 8 patients because of side effects was not complete the course of treatment（the bismuth group three cases,the non-bismuth group 5 cases）.Conclusion：Bismuth-based quadruple therapy and PPI-based quadruple therapy achieved moderate Hp eradication rate.At the same time,the tolerance of patients also affected the eradication rate of Hp.

关 键 词：枸橼酸铋钾 奥美拉唑 四联疗法 幽门螺旋杆菌 根除 

分 类 号：R322.44[医药卫生—人体解剖和组织胚胎学]