Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese  

作　　者：Min Zhang Yan Zhang Shuaishuai Zhu Xiaoyu Li Qing Yang Hui Bai Qi Chen 

机构地区：[1]Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China [2]Department of Medicine, China-Japan Friendship Hospital, Beijing 100029, China

出　　处：《The Journal of Biomedical Research》2012年第6期418-424,共7页生物医学研究杂志（英文版）

基　　金：supported by the 973 Project of National Basic Research Program (No. 2012CB517503 and 2011CB503903);National Natural Science Foundation of China (No. 81070120)

摘　　要：The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 （MSR1） gene, is a pattern recognition receptor （PPR） primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease （CAD） in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms （SNPs） of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio （OR） of 1.56 [95% confidence interval （CI） = 1.28-1.90; P 〈 0.001] and 1.70 （95% CI = 1.27-2.27; P 〈 0.001）, re- spectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD / in combination with traditional risk factors of CAD in Chinese population.The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 （MSR1） gene, is a pattern recognition receptor （PPR） primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease （CAD） in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms （SNPs） of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio （OR） of 1.56 [95% confidence interval （CI） = 1.28-1.90; P 〈 0.001] and 1.70 （95% CI = 1.27-2.27; P 〈 0.001）, re- spectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD / in combination with traditional risk factors of CAD in Chinese population.

关 键 词：class A scavenger receptor gene single nucleotide polymorphisms （SNPs） coronary artery disease Chinese population 

分 类 号：Q51[生物学—生物化学] Q26