模拟体液法快速合成羟基磷灰石纳米针  

Fast Preparation of Nano-sized Needle-like Hydroxyapatite in Simulated Body Fluid

作　　者：金传伟[1,2] 莫祥银[1] 丁毅[2] 

机构地区：[1]南京师范大学分析测试中心.江苏省生物功能材料重点实验室,江苏南京210046 [2]南京工业大学材料科学与工程学院.江苏南京210009

出　　处：《材料科学与工程学报》2012年第6期871-874,879,共5页Journal of Materials Science and Engineering

基　　金：国家重点基础研究发展计划资助项目(973计划)(6134501ZT012004202);江苏省自然科学基金资助项目(2005CCA004,BK2007600);南京师范大学教育部留学回国人员科研启动基金资助项目(2006191XL H0132)

摘　　要：采用模拟体液法快速制备羟基磷灰石(HA)纳米针,并研究了HA生长机制。分析结果表明,仅反应1min就可以获得宽约5nm,长50～80nm且分散良好的HA纳米针,形貌和尺寸与人体骨中的HA极为相似。反应时间影响合成产物的形貌及物相,短时间内延长反应时间有利于HA纳米针的生长,但反应时间超过48h会导致HA与过量的HPO24-反应生成Ca3(PO4)2。Uhrafine hydroxyapatite （HA） needles were prepared rapidly in the simulated body fluid, and the growth mechanism of the HA fine needles was studied. The results showed that well-dispersed HA nanoneedles with about five nanometers in width andfifty to eighty nanometers in length were developed in just one minute. The size and morphology of the synthesized HA are very similar to those of HA in human bone. Reaction time has some effects on both morphology and phase composition of the product. In a short period of time from the beginning the growth of the nano-sized needle-like HA crystals is favored by the time increase. However, when the reaction time is over 48h, HA reacts with excess HPO4,2- to form Ca3 （PO4）2 phase.

关 键 词：羟基磷灰石 模拟体液 纳米针 

分 类 号：R318.08[医药卫生—生物医学工程] TB39[医药卫生—基础医学]