男性高血压患者脑白质变性危险因素分析  

Risk factors for cerebral white matter lesions in male hypertension patients

作　　者：赵素芳[1] 姚晓光[2] 李南方[2] 李文昌[3] 严治涛[2] 程维平[2] 毕云伟[2] 汪迎春[2] 

机构地区：[1]石河子大学医学院研究生院 [2]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所,乌鲁木齐市830001 [3]南开大学档案室,天津市300071

出　　处：《中华实用诊断与治疗杂志》2012年第12期1168-1170,1173,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：新疆维吾尔自治区重点实验室"新疆高血压病研究实验室"开放性课题(XJYS0906-2011-04)

摘　　要：目的探讨男性高血压患者脑白质变性的危险因素。方法完善多导睡眠监测和头颅MRI或CT检查的高血压患者574例,按性别分为男性组(398例)和女性组(176例),检测2组血生化指标,原始变量经主成分法提取因子后,采取最大方差旋转法转换,因子得分进行非条件二分类Logistic回归分析男性高血压患者脑白质变性的危险因素。结果 2组年龄、腹围、吸烟史、饮酒史、高密度脂蛋白胆固醇、三酰甘油、睡眠呼吸暂停低通气指数、阻塞性睡眠紊乱总指数、阻塞性呼吸暂停持续时间、有无阻塞性睡眠呼吸暂停综合征及脑白质变性差异有统计学意义(P<0.05);血压水平(OR=1.97,95%CI:1.32～2.94,P<0.01)及年龄和病程参数(OR=3.29,95%CI:2.27～4.76,P<0.01)是男性高血压患者脑白质变性的独立危险因素。结论积极控制危险因素可延缓男性高血压患者脑白质变性的发生。Objective To study the risk factor for cerebral white matter lesions in male hypertension patients. Methods A total of 574 consecutive hypertension patients （398 males and 176 females） receiving polysomnography plu＇, MRI or CT were retrospectively analyzed. All patients were detected biochemical parameters. Factor analysis was used t~ extract common factors accounting for maiority information of the original variable. Logistic regression analysis was used to study the risk factors of cerebral white matter lesions. Results There were significant differences in age, abdomen circumference, smoking history, drinking history, high density lipoprotein-cholesterol, triacylglycerol, apnea hypopne index, total index of obstructive sleep disorder, mean obstructive sleep apnea duration, obstructive sleep apnoea syndrom（ and cerebral white matter lesions between two groups （P〈0.05）. The level of blood pressure （OR=1.97, 95%CI：1.3 to 2.94,P〈0.01）, age and hypertension duration （OR=3.29, 95%CI： 2.27 to 4.76, P〈0.01） were the independen risk factors for cerebral white matter lesions in male hypertension patients. Conclusion To control risk factors may dela5 the development of cerebral white matter lesions in male hypertension patients.

关 键 词：高血压 男性 脑白质变性 危险因素 血压 年龄 高血压病程 

分 类 号：R544.1[医药卫生—心血管疾病]