ORMDL3基因SNP位点rs7216389多态性与儿童哮喘易感性关系的荟萃分析  

Meta-analysis on ORMDL3 rs7216389 gene polymorphisms and childhood asthma susceptibility

作　　者：崔云霞[1] 张慧姝[2] 师岩[3] 毕慧梅[1] 闫俊霞[1] 周宏博[1,2] 

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室 [2]哈尔滨医科大学生物技术实验教学中心,黑龙江哈尔滨150081 [3]齐齐哈尔医学院生物化学教研室,黑龙江齐齐哈尔161006

出　　处：《哈尔滨医科大学学报》2012年第6期530-533,538,共5页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D201204);教育部黑龙江省部共建心肌缺血机理与诊疗技术重点实验室基金(KF201015)

摘　　要：目的应用荟萃分析方法探讨ORMDL3基因SNP位点rs7216389多态性与儿童哮喘易感性的关系。方法检索Pubmed数据库、Embase数据库、中国知网、万方数据库、维普数据库,收集研究ORM-DL3基因SNP位点rs7216389多态性与儿童哮喘易感性的文献进行荟萃分析。利用STATA10.0软件进行统计学分析。结果根据纳入排除标准,总计纳入6篇文献进行研究,纳入文献均满足Hardy-Weinberg遗传平衡,累计哮喘病例4 046例,对照组3 914例。显性、隐性模型经检验均未发现明显异质性,故采用固定效应模型分析。显性模型(TT+TC)/CC计算总体合并OR值为1.45(95%CI为1.29～1.64),隐性模型TT/(TC+CC)计算总体合并OR值为1.48(95%CI为1.34～1.63)。发表偏倚评估分析未发现明显的发表偏倚,敏感性分析显示荟萃分析结果可信。结论 ORMDL3基因SNP位点rs7216389多态性与儿童哮喘易感性有一定的相关性。Objective To investigate the association between rs7216389 polym6rphisms of ORMDL3 gene and childhood asthma susceptibility by meta-analysis. Methods Five medical databases, including Pubmed database, Emabase database, CNKI database, Wanfang database and Weipu database were searched for all publications on rs7216389 polymorphisms of ORM- DL3 gene and childhood asthma susceptibility. This recta-analysis was assessed by STATA10. 0. Results Based on the inclusion and exclusion criteria, six case-control studies, with 4046 cases and 3914 controls, were included in this recta-analysis. Furthermore, all the ~enotvDefrequencies of control group were consistent with Hardy-Weinberg equilibrium. In addition, no heterogeneity in Tr ＋ TC vs CC model and TY vs TC＋CC model was found, thus fixed-effect model was used. The pooled odd ratios in TY ＋ TC vs CC model and in TT vs TC ＋ CC model were 1.45 （95% CI 1.29 - 1.64） and 1.48 （95% CI 1.34 - 1.63） respectively. Publication bias and sensitivity analysis suggested the reliability of our results. Conclusion The meta-a- nalysis of the case-control studies supports that ORMDL3 rs7216389 polymorphisms are strongly associated with the increased childhood asthma susceptibility.

关 键 词：ORMDL3基因 rs7216389多态性 哮喘 荟萃分析 

分 类 号：R562.25[医药卫生—呼吸系统]