急性上呼吸道梗阻动物模型的制备与急救处理  

Establishment of animal model of acute respiratory tract obstruction and its emergency treatment

作　　者：刘传兰[1] 陆皓[1] 汉瑞娟[1] 孟辉[2] 朱鑫华[1] 李娟[1] 张华[1] 安娟[1] 

机构地区：[1]兰州军区兰州总医院护理部,甘肃兰州730050 [2]兰州军区兰州总医院普胸外科,甘肃兰州730050

出　　处：《西北国防医学杂志》2012年第6期618-620,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：甘肃省科技支撑计划项目(1104FKCA069)

摘　　要：目的:研制严重多发伤、急性上呼吸道梗阻动物模型,探索模型制备后的急救处理。方法:比格犬13只,体质量(14.2±1.2)kg,雌雄不拘,制备严重多发伤、急性上呼吸道梗阻动物模型,随机分为完全性梗阻≤6 min组(A组,n=4),完全性梗阻7～8 min组(B组,n=4),不完全性梗阻≥9 min组(C组,n=5)。3组均按统一检测指标和复苏方法进行各时间段的复苏。结果:各组各时间点生命体征血气的监测指标差异显著。A组6 min开始复苏,全部成活;B组8 min开始复苏,75%成活;C组平均9 min开始复苏,成活率为60%。结论:及时清除呼吸道分泌物和异物,进行有效机械通气,是急性上呼吸道梗阻的急救关键。Objective：To construct the animal model of severe multiple injuries and acute upper respiratory tract obstruction and explore its first aid method.Methods： Thirteen Beagle dogs were used for the model construction,which were randomly divided into three groups： group A（entire obstruction,asphyxiation time ≤6 min,n=4）,group B（entire obstruction,asphyxiation time 7-8 min,n=4）,and group C（partial obstruction,asphyxiation time ≥9 min,n=5）.Three groups were administered with the same measurement indexes and resuscitation methods,and were observed at different time points.Results： There were significant differences in vital signs and blood gas analysis among three groups.All animals recovered successfully in group A,75% animals survived in group B,and 60% animals survived in group C.Conclusion： The important emergency treatment methods for severe multiple injuries and acute upper respiratory tract obstruction should include removing the respiratory secretions and foreign bodies,and effective mechanical ventilation.

关 键 词：上呼吸道梗阻 窒息 严重多发伤 动物模型 急救 

分 类 号：R472[医药卫生—护理学]