臂踝脉搏波速度与缺血性心血管病风险评估程度关系的研究  

Relationship between Brachial Ankel Pulse Wave Velocity and Risk of Ischemic Cardiovascular Disease

作　　者：汤中敏[1] 胡世红[1] 张林潮[1] 韦春凌[1] 韦金儒[1] 廖虹[1] 涂强[1] 李燕丽[1] 沈柳恒[1] 

机构地区：[1]广西医科大学第五附属医院柳州市人民医院,广西柳州市545006

出　　处：《中国全科医学》2012年第35期4055-4057,共3页Chinese General Practice

基　　金：柳州市应用技术研究与开发计划课题项目(2011J0302025)

摘　　要：目的探讨臂踝脉搏波速度(baPWV)与缺血性心血管病(ICVD)危险评估程度之间的关系。方法选择我院健康体检中心行健康体检者3 200例为研究对象,年龄35～64岁,测量身高、体质量、血压;检测空腹血糖、血脂和baPWV;询问有关病史和吸烟史。采用"国人ICVD 10年发病危险简易评估工具"对受检者进行ICVD 10年发病危险评估。以受检者10年ICVD发病绝对风险<5.0%、5.0%～、10.0%～、20.0%～,分别定为低危、中危、高危和极高危4组。分析不同年龄组危险程度的差异、不同危险程度组间baPWV的差异。将baPWV≥1 400 cm/s定为增快,比较各危险程度组baPWV增快检出率的差异;将受检者baPWV与其ICVD危险得分行相关分析。结果 35～组、45～组、55～64岁组危险度间差异有统计学意义(P<0.0001)。3个年龄组,低危受检者baPWV均值间差异有统计学意义(P<0.05),中危、高危和极高危受检者baPWV均值比较,差异均无统计学意义(P>0.05)。低危、中危、高危和极高危组的baPWV均值分别为(1 356±171)、(1 626±220)、(1 786±307)和(2 032±458)cm/s,组间差异有统计学意义(P<0.0001)。低危组baPWV增快率为35.9%(1 042/2 916),中危组为88.1%(182/202),高危组为91.9%(55/56),极高危组为100.0%(37/37),4个危险度组baPWV增快率间差异有统计学意义(P=0.0001)。baPWV值与ICVD危险评分间呈正相关(r=0.67,P=0.0001)。结论 baPWV与ICVD 10年发病危险度有密切关系,其增快可预测ICVD发病风险,有助于检出危险人群,值得推广应用。Objective To explore the relationship between brachial ankle pulse wave velocity （baPWV） and ischemic cardiovascular disease （ICVD）. Methods A total of 3 200 healthy subjects who had taken health check - up in our center from October 2009 to December 2011 were enrolled in this study. There height, weight, blood pressure, fasting blood sugar, blood lipids, and baPWV were measured. Their diseases histories and smoking history were recorded. The ＂ Simplified Evaluation Tool of ICVD 10 - year Onset in China＂ was adopted fore the risk evaluation. Subjects with 10 - year ICVD absolute risks 〈 5.0% , 5.0% -10.0%, or 〉20.0%, were enrolled into four groups： low -risk, intermediate -risk, high -risk, and ex- tremely high -risk groups. The differences in risk degrees among different age groups were analyzed. A baPWV ≥ 1 400 cm/s was defined as increasing fast. The percentages of fast detection rate was compared among these four groups. Univariate analysis was performed between the individual baPWV value and the score of ICVD risks. Results The risk degree was significantly dif- ferent among the 34 -44 age group, 45 - 54 age group, and 55 -64 age group （P 〈 0. 001 ）. Among these three age groups, the baPWV was significantly different within the low - risk group （P 〈 0. 05 ）, while no such difference was seen in the interme- diate - risk, high - risk, and extremely high - risk groups （ P 〉 0. 05 ）. The average baPWV values in the low - risk, interme- diate -risk, high -risk, and extremely high -risk groups were （1 356±171）, （1 626±220）, （1 786±307）, and （2 032 ± 458 ） era/s, respectively （ P 〈 0. 0001 ）. Subjects with higher baPWV in the low - risk, intermediate - risk, high - risk and extremely high-risk groups accounted for 35.9% （1 042/2 916）, 88.1% （182/202）, 91.9% （55/56）, and 100.0% （37/ 37 ）, respectively （P 〈 0. 0001 ）. Monovariate analysis showed a correlation between PWV value and scores of ICVD risk （r = 0. 67, P = 0. 0001 ）.

关 键 词：心血管疾病 危险性评估 脉搏波速度 风险预测 

分 类 号：R54[医药卫生—心血管疾病]