冠状动脉无复流的研究进展  

Research Progress of Coronary No-reflow

作　　者：张金刚[1,2] 史晓俊[3] 王本芳[3] 

机构地区：[1]蚌埠医学院第一附属医院,安徽省蚌埠市233000 [2]蚌埠医学院 [3]蚌埠医学院第一附属医院心内科,安徽省蚌埠市233000

出　　处：《中国全科医学》2012年第36期4160-4162,共3页Chinese General Practice

摘　　要：无复流现象是指接受直接经皮冠状动脉介入治疗的心肌梗死患者,尽管梗死相关血管开通,但是心肌组织仍然灌注不足,其与不良的临床结果和预后有关。无复流是一个很复杂的现象,有缺血性损伤、远端栓塞、再灌注损伤和个体易患性等多种发病机制。对这些发病机制采取合适的预防和治疗策略有望减少无复流的发生。本文主要阐述了无复流现象的发病机制及其预防和治疗研究进展。The myocardial no- reflow phenomenon is characterized by a reduced antegrade myocardial blood flow de- spite an open infarct -related artery in patients with myocardial infarction undergoing primary percutaneous coronary intervention. Importantly, no -reflow is known to be associated with unfavorable clinical outcome and prognosis. It is a complex phenomenon and caused by the variable combination of 4 pathogenetic components： distal atherothrombotic embolization, ische- mie injury, reperfusion injury and individual susceptibility. So, appropriate strategies of prevention and treatment are expected to reduce the occurrence of no - reflow. This article mainly explains the research progress of no reflow phenomenon of prevention and treatment.

关 键 词：冠状动脉疾病 无复流现象 治疗 

分 类 号：R541.4[医药卫生—心血管疾病]