高血压前期体检人群体质指数对24h动态血压监测血压水平的影响研究  

Effect of Body Mass Index on Parameters of Ambulatory Blood Pressure Monitoring in Population with Pre-hypertension Examination

作　　者：李曦[1] 胡荣[1] 芦燕玲[1] 于利群[1] 周生来[1] 

机构地区：[1]首都医科大学附属北京安贞医院健康管理中心,北京市100029

出　　处：《中国全科医学》2012年第31期3606-3609,共4页Chinese General Practice

基　　金：十一五国家科技支撑计划基金项目(2008BAI52B06)

摘　　要：目的探讨高血压前期体检人群血压水平与体质量之间的关系,为临床防治高血压提供参考。方法选择2007年1月—2011年12月我院体检中心体检者共243例,根据体质指数分为正常体质量组(18.5 kg/m2≤体质指数<24.0 kg/m2)、超重组(24.0 kg/m2≤体质指数<28.0 kg/m2)和肥胖组(体质指数≥28.0 kg/m2)。采用日立7600-120全自动生化仪检测其血糖、肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);SECA身高体质量检测仪测量身高和体质量,体质指数=体质量(kg)/身高2(m2);标准汞柱血压计测量白天静息15 min后的坐位血压;美林公司Accuwin 2.0血压监测仪监测24 h动态血压,记录仪自动记录并统计分析以下指标:24 h平均血压、白天平均血压、夜间平均血压、白天和夜间血压负荷、白天和夜间血压变化标准差。结果 3组体质指数、血糖、TG及HDL-C水平比较,差异均有统计学意义(P<0.01),Cr、TC、LDL-C水平比较,差异均无统计学意义(P>0.05)。3组24 h平均舒张压、白天平均舒张压、夜间平均舒张压、白天舒张压变化标准差、白天舒张压负荷、夜间舒张压负荷比较,差异均有统计学意义(P<0.05),24 h平均收缩压、白天平均收缩压、夜间平均收缩压、白天收缩压变化标准差、夜间收缩压变化标准差、夜间舒张压变化标准差、白天收缩压负荷、夜间收缩压负荷比较,差异均无统计学意义(P>0.05)。Pearson相关分析显示,体质指数与24 h平均收缩压(r=0.128)和舒张压(r=0.188)、白天平均收缩压(r=0.154)和舒张压(r=0.186)、夜间平均舒张压(r=0.148)、白天收缩压负荷(r=0.126)和舒张压负荷(r=0.146)、白天舒张压变化标准差(r=0.253)、夜间舒张压变化标准差(r=0.190)均呈正相关(P<0.05)。调整年龄、性别、吸烟、饮酒、血糖、Cr、TC、TG、HDL-C、LDL-C等因素后进行多元线性回归分析发现,体质指数与24 hObjective To investigate relationship between body mass index（BMI） and parameters from ambulatory blood pressure monitoring in population who underwent pre-hypertension examination.Methods Totally 243 persons who underwent pre-hypertension examination form January 2007 to December 2011 in our physical examination center were recruited.They were divided based on their BMI as normal group（18.5 kg/m2≤BMI24.0 kg/m2）,overweight group（24.0 kg/m2≤BMI28.0 kg/m2） and obesity group（BMI≥28.0 kg/m2）.The parameters of blood sugar,creatine（Cr）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were assyed by Hitachi 7600-120 automatic biochemistry analyzer.The body height and BMI were measured by SECA height and BMI meter,BMI=weight（kg）/height2（m2）.The blood pressure at setting position was taken by Standard mercury sphygmomanometer 15 min after rest in daytime.The ambulatory blood pressure monitoring was conducted by using Accuwin 2.0 of Merrill Lynch.Results Among the three groups there were no significant differences in BMI,blood sugar,TG and HDL-C（P0.01）,but there were in Cr,TC,LDL-C（P0.05）.And there were significant differences in 24 h average diagnostic blood pressure,average diagnostic blood pressure in daytime and at night,standard deviation of daytime diagnostic blood pressure,loads of daytime and night diagnostic blood pressure（P0.05）;but no significant difference was found in 24 h average systolic blood pressure,systolic blood pressure in daytime and at night,standard deviations of daytime and night systolic blood pressure,standard deviation of night diagnostic blood pressure,and loads of daytime and night systolic blood pressure（P0.05）.Pearson correlation analysis showed that the BMI was positively correlated with the 24 h average systolic and diagnostic blood pressure（r=0.128,r=0.188）,daytime average systolic and diastolic blood pressure（r=0.154,r=0.186）,night ave

关 键 词：人体质量指数 高血压 血压监测 便携式 高血压前期 

分 类 号：R544.1[医药卫生—心血管疾病]