缩宫素在超声消融治疗子宫腺肌症时的作用评价  

Effects of oxytocin on high intensity focused ultrasound ablation of adenomysis

作　　者：张昕[1] 何佳[1] 毛世华[1] 王健[1] 何敏[1] 吴庆蓉[1] 张瑞涛[1] 张炼[1] 

机构地区：[1]重庆医科大学生物医学工程学院超声医学研究所,400016

出　　处：《重庆医学》2012年第36期3825-3827,共3页Chongqing medicine

基　　金：国家自然科学基金重点项目(30830040);国家"十一五"科技支撑计划资助项目(2006BAI03A02);重庆市科委攻关项目[(2007)11CSTC;2007AA502]

摘　　要：目的评价缩宫素对超声消融子宫腺肌症治疗剂量的影响及在超声消融治疗过程中使用的安全性。方法 86例确诊的子宫腺肌症患者随机分为缩宫素组和对照组进行超声消融治疗,比较两组间的消融效果及相关不良反应。结果缩宫素组病灶体积消融率为(80.7±11.6)%,能效因子(EEF)为(8.1±9.8)J/mm3,消融单位体积所需时间为(30.0±36.0)s/cm3;对照组病灶体积消融率为(70.8±16.6)%,EEF为(15.7±19.5)J/mm3,消融单位体积所需时间为(58.1±72.7)s/cm3。两组以上指标比较,差异有统计学意义(P<0.05)。两组均无严重不良反应。结论缩宫素能降低超声消融子宫腺肌症所需的能量,提高治疗效率,具有很好的临床应用价值。Objective To explore the effects of oxytocin on the dosage of high intensity focused ultrasound（HIFU） ablation of adenomysis and safety during the treatment.Methods 86 patients with adenomyosis from three hospitals were treated with ultrasound guided HIFU.The patients were randomly assigned in oxytocin group or control group.Then compare the ablation effect and related adverse reactions between two groups.Results In the oxytocin group,the non perfused volume（NPV） ratio was（80.7±11.6）%;the EEF was（8.1±9.8）J/mm3,sonication time required to ablate 1 cm3 was（30.0±36.0）s/cm3.In the control group,the non perfused volume ratio was（70.8±16.6）%,EEF was（15.7±19.5） J/mm3,sonication time required to ablate 1 cm3 was（58.1±72.7）s/cm3.Significant difference in NPV ratio,EEF,sonication time required to ablate 1 cm3 between the two groups were observed（P0.05）.No severe adverse reactions were found in both groups.Conclusion Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU and enhance the treatment efficiency.It has a good clinical application value.

关 键 词：催产素 超声消融 子宫腺肌症 

分 类 号：R711.71[医药卫生—妇产科学]