盐酸普萘洛尔单向灌流法大鼠在体肠吸收的研究  

A study of rat in situ intestinal absorption of propranolol hydrochloride through single pass perfusion method

作　　者：张小华[1] 陈力学[2] 贾毅敏[1] 

机构地区：[1]重庆市肿瘤研究所药剂科,400030 [2]重庆医科大学附属第一医院实验研究中心,400016

出　　处：《重庆医学》2012年第36期3871-3873,共3页Chongqing medicine

摘　　要：目的研究盐酸普萘洛尔(PNH)的肠吸收情况,为制剂合理选择处方和临床药代动力学与药效学的深入研究奠定基础。方法采用大鼠单向灌流模型,引入了重量法来标示灌流液体积。考察药液浓度和pH值对肠吸收的影响。结果 PNH在全肠道均有良好的吸收,且吸收不受药物浓度和pH值的影响。结论可以考虑将PNH制成匀速释放的剂型。Objective To study the intestinal absorption of propranolol hydrochloride for rational selection of formulation and further study of pharmacokinetics and pharmacodynamics.Methods Rat single pass perfusion method was used.Weight method was selected to indicate the volume of perfusion fluid.The effects of concentration and pH of drug solution on intestinal absorption were evaluated.Results Propranolol hydrochloride has good absorption in the entire intestinal tract.The absorption is not affected by concentration and pH of drug solution.Conclusion Propranolol hydrochloride could be prepared into dosage forms which release drug constantly.

关 键 词：大鼠 盐酸普萘洛尔 单向灌流法 在体肠吸收 

分 类 号：R965[医药卫生—药理学]