头孢噻呋钠在成年麻鸭体内的药代动力学研究  

Studies on Pharmacokinetics of Ceftiofur Sodium in Brown Ducks

作　　者：徐俊[1] 曹芳元[1] 徐敏[1] 祝圆[1] 邱银生[1] 

机构地区：[1]武汉工业学院动物科学与营养工程学院,武汉430023

出　　处：《中国兽药杂志》2012年第9期18-21,共4页Chinese Journal of Veterinary Drug

摘　　要：研究头孢噻呋钠在成年麻鸭体内的药动学特征及生物利用度,为兽医临床制定合理的给药方案提供科学依据。选取24只健康的成年麻鸭,随机分为3组,以2 mg/kg剂量分别单次肌内注射、静脉注射和内服头孢噻呋钠,采用HPLC法检测血药浓度,计算头孢噻呋的药动力学参数和肌注、内服的生物利用度。结果表明:静脉注射头孢噻呋钠后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.19±0.22)h,t1/2β为(3.64±0.22)h,Vd为(0.48±0.06)L/kg,CL为(0.07±0.01)L/(kg.h),AUC为(27.09±2.84)μg/(mL.h);肌内注射后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.38±0.02)h,t1/2β为(4.56±0.29)h,Tmax为(0.49±0.17)h,Cmax为(6.44±0.44)μg/mL,AUC为(26.88±0.49)μg/(mL.h),生物利用度为99.22%;内服后,血药浓度经时数据符合二室开放模型,主要动力学参数:t1/2α为(0.77±0.14)h,t1/2β为(3.81±0.23)h,Tmax为(1.06±0.23)h,Cmax为(3.62±0.20)μg/mL,AUC为(21.47±0.44)μg/(mL.h),生物利用度为79.25%。头孢噻呋钠在成年麻鸭体内吸收迅速,半衰期较长,肌注的生物利用度高,内服吸收良好。Pharmacokinetics and bioavailability of ceftiofur sodium in adult brown ducks were studied to provide a scientific basis for a reasonable clinical program.24 healthy adult brown ducks which had been divided into three group were respectively administrated of ceftiofur sodium（2 mg/kg） by intramuscular injection,intravenous injection and oral gavages.The drug concentrations in plasma of ducks in each group were detected with high-performance liquid chromatogram（HPLC）,and the pharmacokinetic parameters and the bioavailability were analyzed with Drug and Statistics（DAS）.The results showed that the drug concentration-time data of ceftiofur following intravenous injection administration was well described by a two-compartment open model.The main parameters were as follow：t1/2α=（0.19±0.22）h,t1/2β=（3.64±0.22）h,Vd=（0.48±0.06）L/kg,CL=（0.07±0.01）L/（kg·h）,AUC=（27.09±2.84）μg/（mL·h）.The drug concentration-time data of ceftiofur following intramuscular injection administration was well described by a two-compartment open model.The parameters were as follow：t1/2α=（0.38±0.02）h,t1/2β（4.56±0.29）h,Tmax=（0.49±0.17）h,Cmax=（6.44±0.44）μg/mL,AUC=（26.88±0.49）μg/（mL·h） and the bioavailability was 99.22%;The drug concentration-time data of ceftiofur following oral administration was well described by a two-compartment open model.The main parameters were as follow：t1/2α=（0.77±0.14）h,t1/2β=（3.81±0.23）h,Tmax=（1.06±0.23）h,Cmax=（3.62±0.20）μg/mL,AUC=（21.47±0.44）μg/（mL·h）,and the bioavailability was 79.25%.These results showed that ceftiofur was rapidly absorbed and had a long half-time in brown ducks.Ceftiofur had a high rate of bioavailability by intramuscular injection and was well absorbed by oral administration.

关 键 词：头孢噻呋钠 麻鸭 药代动力学 生物利用度 

分 类 号：S859.7[农业科学—临床兽医学]