长效土霉素注射液在猪体内的药动学及相对生物利用度研究  

Pharmacokinetics and Relatively Bioavailability of Oxytetracycline Long Acting Injection in Swine

作　　者：廖雪玲 张炳旭[2] 丁焕中[2] 

机构地区：[1]上海公谊兽药厂,上海201401 [2]华南农业大学兽医学院,广州510642

出　　处：《中国兽药杂志》2012年第12期19-21,39,共4页Chinese Journal of Veterinary Drug

基　　金：国家自然科学基金资助项目(31172366)

摘　　要：对7头健康猪随机交叉设计进行单剂量肌肉注射国产30%长效土霉素注射液和进口20%长效土霉素注射液药动学试验,给药剂量以土霉素计均为20 mg/kg体重。用高效液相色谱法测定血药浓度,血药浓度-时间数据用MCPKP计算机程序处理。30%长效土霉素注射液和20%长效土霉素注射液主要药动学参数分别为:吸收半衰期(t1/2Ka)为(0.088±0.016)、(0.140±0.076)h;消除半衰期(t1/2β)为(52.499±22.885)、(36.481±21.673)h;达峰时间(Tmax)为(0.609±0.100)、(0.832±0.373)h;峰浓度(Cmax)为(4.956±1.171)、(5.018±0.948)μg/mL;药时曲线下面积(AUC)为(112.483±18.135)、(109.877±19.949)mg/L.h;以20%长效土霉素注射液为对照物,30%长效土霉素注射液的相对生物利用度(F)为(105.368±26.027)%。结果表明,国产30%长效土霉素注射液与进口20%长效土霉素注射液相比,主要药动学参数无显著差异。此结论为临床合理使用该剂型提供了依据和指导。The pharmacokinetics and relatively bioavailability of oxytetracycline long acting injection were investigated in 7 healthy swine by a random cross experimental design. Animals were intramuscularly administrated 30% oxytetracycline long acting injection and 20% terramycin long acting injection, all at the single dose of 20 mg/kg body weight. The plasma concentrations of oxytetracycline were determined by HPLC method. The plasma concentration- time data obtained from experiments were analyzed using MCPKP program. The main pharmacokinetic parameters for 30% terramycin long acting injection and 20% terramycin long acting injection administrated intramuscularly were as follows respectively： tl/EKa （0. 088 ± 0.016） and （0. 140 ± 0. 076） h, t1/2β （52.499 ±22.885） and （36.481 ±21.673） h, Tmax（0.609 _0. 100） and （0.832 ±0.373） h, Cmax（4. 956 ± 1.171） and （5.018 ±0.948） μg/mL, AUC （112.483 ±18. 135） and （109.877±19.949） mg/L · h,F（105.368 ±26.027）%. These results showed that there was no signifi pharmacokinetic parameters of 30% oxytetracycline long acting injection and 20%

关 键 词：土霉素 长效注射液 药动学 相对生物利用度 猪 

分 类 号：S859.796[农业科学—临床兽医学]