抗精子抗体与精液常规参数的相关性调查  

An investigation of the correlation of anti-sperm antibodies and semen parameters

作　　者：吕俊霞[1] 杨大干[1] 姚冬英[1] 沈乃仙[1] 

机构地区：[1]浙江大学医学院附属第一医院检验科,杭州310003

出　　处：《检验医学与临床》2012年第24期3041-3042,3044,共3页Laboratory Medicine and Clinic

基　　金：浙江省人口和计划生育委员会科技项目;编号:2010-KY-1-28

摘　　要：目的调查抗精子抗体(AsAb)对精液常规参数的影响。方法选取AsAb阳性组51例、AsAb阴性组40例和健康对照组47例,采用计算机辅助精子分析仪检测精液参数,用SPSS 15.0软件进行统计学分析。结果 AsAb阳性组的精子活率(%)、a+b级活力(%)和畸形率(%)分别为(62.62±10.49)%、(30.81±9.00)、(63.04±7.55)%;AsAb阴性组3项分别为(66.44±8.25)%、(31.40±9.08)%、(65.77±8.76)%;健康对照组3项分别为(68.73±4.76)%、(35.99±6.44)%、(60.85±5.96)%。上述各指标在3组间差异均有统计学意义(P<0.05)。AsAb主要结合于精子的尾部。结论 AsAb阳性可能是患者的精子活率和a+b级活力降低的原因之一。Objective To investigate the influence of anti-sperm antibodies （AsAb） on sperm parameters. Methods The subjects consisted of 51 AsAb positive patients,40 diseased control and 47 healthy control cases. The semen parameters were detected by computer-assisted sperm analyzer,and SPSS 15.0 was used for statistical analysis. Results The sperm motility（%）,a＋b-level activity（%）,and malformation rate（%）were 62.62±10.49,31.81±9.00,and 63.04±7.55 respectively in the AsAb positive group these were 66.44±8.25,31.40±9.08,and 65.77 ±8.76 respectively in the diseased control group and 68.73±4.76,35.99± 6.44,and 60.85±5.96 respectively in the healthy control group. There were significant differences between 3 groups as to the above mentioned parameters （F values were 6. 490,4. 979,and 4. 140 respectively,P〈0.05）. The AsAb mainly adhered to the tails of sperms. Conclusion AsAb positive may be one of the reasons for decreased sperm motility and vitality of a＋b level.

关 键 词：抗精子抗体 精子活率 男性不育 

分 类 号：R711.6[医药卫生—妇产科学]