3项联合检测对类风湿关节炎的诊断价值  

Clinical investigation of combined determination of serum RF,AKA and antiCCP antibody levels in patients with rheumatoid arthritis

作　　者：张福军[1] 王厚照[1] 马莉[1] 

机构地区：[1]解放军第174医院检验科,福建厦门361003

出　　处：《检验医学与临床》2012年第24期3074-3075,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨类风湿因子(RF)、抗环瓜氨酸多肽抗体(抗CCP)和抗角蛋白抗体(AKA)在类风湿关节炎(RA)中联合检测的价值。方法采用化学发光方法测定抗CCP,采用间接免疫荧光法检测AKA,采用免疫比浊法测定RF。结果抗CCP的阳性率在RA患者中为65.45%,在非RA中为3.33%,并且3项指标对RA诊断的敏感性和特异性分别为抗CCP 65.45%;97.83%,AKA 33.64%、96.83%;RF 75.45%、78.98%。RA患者的3项指标阳性率均明显高于非RA患者和健康体检者,差异有统计学意义(P<0.05)。结论抗CCP具有较好的灵敏度和特异性;联合检测抗CCP、AKA与RF可明显提高对RA诊断的特异性。Objective To assess the value of joint detection of RF,Anti- CCP and AKA for diagnosis of rheumatoid arthritis（RA）. Methods Anti-CCP antibody was detected by chemiluminescence immunoassay method,AKA was detected by indirect immunofluo rescence test,RF was detected by immune method. Results The positive rate of the anti-CCP antibody was 66.45 % in RA patients and 3.33% in non RA patients. The sensitivity and specificity of anti-CCP,AKA and RF were 66.45% and 97.83 %,33.64 % and 96.83%,75.45% and 78.98%. The positive rate of three antibodies in RA patients were significantly higher than non-RA patients and normal healthy people（P〈 0.05）. Conclusion Anti-CCP has relatively higher sensitivity and specificity in the diagnosis of rheumatoid arthritis. The combined detection of anti-CCP,AKA and RF can improve the specificity of diagnosis of RA.

关 键 词：类风湿关节炎 抗环瓜氨酸多肽抗体 抗角蛋白抗体 类风湿因子 

分 类 号：R593.22[医药卫生—内科学]