NVB联合顺铂治疗蒽环类化疗后的晚期乳腺癌30例疗效分析  

Clinical efficacy of NVB combined with cisplatin for 30 cases of advanced breast cancer after anthracycline chemotherapy

作　　者：陈赞青 南桂萍 

机构地区：[1]樟树市人民医院内一科,331200

出　　处：《国际医药卫生导报》2012年第24期3573-3575,共3页International Medicine and Health Guidance News

摘　　要：目的观察NVB联合顺铂治疗蒽环类化疗后晚期乳腺癌的临床疗效。方法：悔我院2010年9月至2011年8月我院收治的60例蒽环类化疗后晚期乳腺癌患者按照随机数表分为试验组和对照组各30例，试验组应用NVB联合顺铂治疗，对照组持续使用蒽环类化疗，观察疗效。结果试验组治疗有效率为43.3％，高于对照组的13．3％，差异有显著性（P〈0．05）。经3个疗程后，所有患者均无严重肝功能损伤，主要用药毒副作用为骨髓抑制、胃肠道反应和脱发，少数患者表现为外周神经毒性和静脉炎，在骨髓抑制方面试验组优于对照组（P〈0．05）。结论NVB是蒽环类化疗后晚期乳腺癌患者的首选治疗方案，值得推广应用。Objective To observe the clinical efficacy of NVB combined with cisplatin for patients with advanced breast cancer after anthracycline chemotherapy. Methods 60 cases of advanced breast cancer after anthracycline chemotherapy, admitted into our hospital from Sep 2010 to Aug 2011, were randomly divided into 2 groups： 30 patients in a test group got the treatment of NVB combined with cisplatin; 30 patients of the control group continued use of anthracycline chemotherapy. The treatment efficacy was calculated and observed.Results Effective rate （CR ＋ PR） in test group was 43.3%, which was higher than that （13.3%）in the control group, and the difference was statistically significant （P〈0.05）. After 3 courses of treatment, all patients had no severe liver functional damage occurred, and the main drug toxicity manifested as bone marrow suppression, gastrointestinal reactions, and hair loss; in addition, a small number of patients showed peripheral neurotoxicity and phlebitis; the difference of bone marrow suppression between 2 groups was statistically significant （P〈0.05）.Conclusion The treatment of NVB combined with eisplatin for the patients with advanced breast cancer after anthracycline chemotherapy is the best choice, which should be widely applied.

关 键 词：长春花碱 顺铂 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]