新生儿呼吸衰竭时血浆β-内啡肽水平的变化  

The concentration changes of β-endorphin in full-term newborns with respiratory failure

作　　者：李梅 周东元 闫丽 刘国慧 李新秀[2] 张剑珲 王书伟 王祥 赵惜霜 李伯茹[2] 

机构地区：[1]黑龙江省哈尔滨市儿童医院急救中心,150010 [2]哈尔滨市第一医院妇产科

出　　处：《中华儿科杂志》2000年第6期355-357,共3页Chinese Journal of Pediatrics

摘　　要：目的　探讨血浆 β 内啡肽 (β EP)在新生儿呼吸衰竭中的作用。方法　应用放射免疫法分别在入院时、入院 72h或死亡前以及恢复期测定 46例 (新生儿窒息 31例、新生儿肺炎 15例 )呼吸衰竭 (简称呼衰 )的足月新生儿 ,血浆 β EP含量 ,并与不伴有呼衰的 17例 (新生儿窒息 9例、新生儿肺炎 8例 )对照组患儿和 2 0例足月健康新生儿作对照。结果　入院时呼衰组血浆 β EP含量明显高于对照组和健康组 (P均 <0 .0 1) ,II型呼衰组 (n =2 9)显著高于I型呼衰组 (n =17) (P <0 .0 1)。窒息呼衰组血浆 β EP含量均高于相应的肺炎患儿 (P <0 .0 5 )。呼衰组中死亡的 2 2例患儿入院 72h的血浆β EP含量明显高于该组存活者 (n =2 4) (P <0 .0 5 )。窒息呼衰组中 β EP含量与pH、PaO2 呈负相关(P <0 .0 5 ) ,与PaCO2 呈正相关 (P <0 .0 5 ) ;当严重低氧 (PaO2 ≤ 35mmHg)、严重酸中毒 (pH≤ 7.0 )时β EP含量极度升高 (P <0 .0 5 )。结论　β EP可能在新生儿呼衰中起促进作用。Objective To explore the role of β-endorphin (β-EP) in neonatal respiratory failure. Methods Plasma β-EP levels of 46 full-term newborns with the neonatal respiratory failure, which including 31 cases as asphyxia group and 15 cases as pneumonia group, were measured by radioimmunoassay at the time of admission to the hospital,72 hours after admission or before the death, and in recovery phase. Seventeen newborns without the respiratory failure (9 with asphyxia and 8 with pneumonia) and 20 healthy neonates were included as controls. Results Plasma β-EP levels of respiratory failure group were significantly higher than those of control group and healthy group at the time of admission to the hospital ( P <0.01). Plasma β-EP levels were remarkably higher in the patients with severe respiratory failure ( n =29) than those with mild respiratory failure group ( n =17, P <0.01). Plasma β-EP levels were also higher in respiratory failure newborns with the asphyxia than those in respiratory failure newborns with pneumonia. Plasma β-EP levels of the dead patients ( n =22) in respiratory failure group were significantly higher than those of the survivors ( n =24) 72 hours after the hospitalization. The concentration of plasma β-EP showed a negative correlation with pH and PaO 2( P <0.05) and a positive correlation with PaCO 2( P <0.05) in the group of asphyxia newborns with the respiratory failure. Newborns with severe hypoxia (PaO 2≤35 mm Hg) or severe acidosis (pH≤7.0) presented much higher plasma β-EP levels ( P < 0.05). Conclusion β-EP may play some roles in respiratory failure of newborns.

关 键 词：新生儿 Β-内啡肽 呼吸衰竭 放射免疫测定 

分 类 号：R722.12[医药卫生—儿科]