头孢曲松与诺氟沙星对比治疗小儿耐药伤寒60例  

Ceftriaxone vs. norfloxacin in the treatment of resistant typhoid fever in 60 children

作　　者：怀有为[1] 朱启镕[1] 王晓红[1] 

机构地区：[1]上海医科大学附属儿科医院感染科,200032

出　　处：《中华儿科杂志》2000年第6期386-388,共3页Chinese Journal of Pediatrics

摘　　要：目的　比较头孢曲松 (罗氏芬 )与诺氟沙星治疗小儿耐药伤寒的疗效。方法　 6 0例耐药伤寒患儿随机分为两组 ;头孢曲松组 30例 ,用头孢曲松 [10 0mg/ (kg·d) ,1次静脉给药 ],诺氟沙星组 30例 ,用诺氟沙星 [10～ 2 0mg/ (kg·d) ,分 2次口服 ]。结果　头孢曲松总有效率为 93% (2 8/ 30 ) ,而诺氟沙星组为 80 % (2 4/ 30 ) (P <0 .0 1)。结论　头孢曲松治疗小儿耐药伤寒效果优于诺氟沙星。Objective To compare the effect of ceftriaxone and norfloxacin on resistant typhoid fever inchildren. Methods Sixty children with typhoid fever resistant to chloramphenicol, ampicillin or cotrimoxazolewere randomly divided into two groups. Thirty cases received ceftriaxone [100mg/(kg d), once daily, iv] and the other 30 received norfloxacin [10 mg/(kg d), twice daily]. Results Ceftriax one was effective in 93% of the 30 cases, while norfloxacin was effective in 80% of the 30 cases (Ridit analysis, ceftriaxon(R = 0.4211,norfloxacin (R = 0.578 9, u = 2. 12, P < 0.05). Conclusion The therapeutic effect of ceftriaxone on drugresistant typhoid fever in children was better than that of norfloxacin.

关 键 词：伤寒 头孢曲松 诺氟沙星 儿童 对比治疗 

分 类 号：R725.1[医药卫生—儿科]