类风湿关节炎蛋白质组学研究进展  

Proteomics in Rheumatoid Arthritis

作　　者：王梅[1,2] 刘素苗[1,2] 张莉芸[1,2] 

机构地区：[1]山西医科大学 [2]山西大医院风湿免疫科

出　　处：《中华临床免疫和变态反应杂志》2012年第4期308-312,共5页Chinese Journal of Allergy & Clinical Immunology

摘　　要：蛋白质组学技术通过在蛋白质水平上对机体进行研究以阐述疾病的发生、发展及转归。将蛋白质组学技术应用于类风湿关节炎(RA)的研究,多项研究均证实钙连蛋白A(MRP-8)等蛋白质与RA滑膜局部炎性反应有关,可能参与RA发病。应用表面增强激光解析电离飞行时间质谱技术结合决策树统计方法可建立RA的疾病诊断预测模型。Proteomics technology is applied to explain the occurrence, development and prognosis of a disease though the research at the protein level. This technology has been used in the study of rheumatoid arthritis （RA）. A number of studies have confirmed that calgranulin A was related to local inflammation on RA synovium and may participate in the pathogenesis of RA. Combining surface enhanced laser desorption ionization time of flight mass spectrometry technology and statistical methods can create a decision tree of predictive model for diagnosis.

关 键 词：蛋白质组学 类风湿关节炎 钙连蛋白A 

分 类 号：R593.22[医药卫生—内科学] R329.26[医药卫生—临床医学]