HPLC法测定脑络通胶囊中盐酸托哌酮的含量  

Determination of Tolperisone Hydrochloride in Naoluoton Capsules by HPLC

作　　者：罗茂芝 郑文涛 李玲珍 

机构地区：[1]广东邦民制药厂有限公司,江门529080

出　　处：《光明中医》2012年第5期886-887,共2页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的 HPLC法测定脑络通胶囊中盐酸托哌酮的含量。方法采用AgilentC18色谱柱(150mm×4.6mm),以乙腈-磷酸二氢钾(25:75)为流动相,检测波长256nm。结果盐酸托哌酮在0.6～6μg范围内线性良好,r=0.9993(n=5),平均回收率为99.2%,RSD(n=5)为0.1%(n=5)。结论方法简便可行,重现性好,能有效控制产品质量。Objective To establish an HPLC Method for the Determination of hydrochloride in Naoluoton Capsules.Method Agilent C18 was used The mobile phase was acet onitrile-monopotassiun phosphate kdp（25：75）,detective wavelength was 256 nm。Results Thegood linear range of Tolperisone hydrochloride was 0.6μg～6μg,r=0.9999（n=5）,the average recovery was 99.2%,RSD 0.1%（n=5）。 Conclusion The mobile was simple and accurate,It can be wsed for quality control of Naoluot on Capsules。

关 键 词：脑络通胶囊 HPLC 盐酸托哌酮 

分 类 号：R927.2[医药卫生—药学]