实验性胰腺炎大鼠血浆ET和PGI_2水平的改变及川芎嗪治疗的影响  

The Changes of Plasma ET and PGI 2 in Experimental Pancreatitis in Rats and the Therapeutic Influence of Tetramethylprazine

作　　者：李革[1] 申容硕[1] 姜惟龙[1] 

机构地区：[1]吉林省延吉市延边大学医学院附属医院,延吉133000

出　　处：《中国中西医结合外科杂志》2000年第3期186-188,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的 :探讨内皮素 (ET)与前列环素 (PGI2 )在急性出血坏死性胰腺炎 (AHNP)病理生理中的作用及川芎嗪 (TMP)治疗意义。 方法 :动态测定AHNP大鼠血浆ET和PGI2 水平 ,观察胰腺组织形态及大鼠的存活率 ,并观察TMP对它们的影响。结果 :AHNP大鼠术后随时间延长 ,血浆ET含量及ET/PGI2 比值递增 ,胰腺组织病理形态损害加重 ,均较假手术组有显著性差异 (P <0 .0 5 ) ;腹腔注射TMP组血浆ET含量及ET/PGI2 比值较之降低 ,且ET/PGI2 比值接近正常 ,胰腺出血坏死程度及腺泡细胞超微结构破坏减轻 ,大鼠存活率提高 ,均较AHNP对照组有显著性差异 (P <0 .0 5 )。 结论 :AHNP大鼠早期存在着ET与PGI2 平衡失调 ,此平衡失调可通过胰腺血循环障碍而在AHNP大鼠病理生理中起重要作用。TMP对AHNP大鼠有一定治疗作用 ,可能与纠正ET、PGI2 失衡从而改善胰腺微循环、降低血清淀粉酶有关。Objective:To study the functioin of endothelin and PGI 2 in pathophysiology of AHNP(acute hemorrhagic necrotizing pancreatitis),and the therapeutic effect of Tetramethylpyrazine Methods:To investigate the changes of ET(Endothelin),prostacyclin(PGI 2)levels,ET/PGI 2 and pancreatic pathomorphology,survival rate in AHNP and effects of TMP(tetramethylpyrazine)on the above mentioned experimental value.Results:In comparison with the control group,the value of plasma ET,ET/PGI 2 were much higher and the pathologic lesions of pancreatic tissue were much severe in rats with AHNP( P<0.05 ),so there is an unbalanced phenomenon on the ratio of ET/PGI 2;TMP caused a remarkable decrease in both the level of ET and ratio of ET/PGI 2.It improved the pathologic changes and survival rate.Conclusion:ET and ET/PGI 2 play an important role in the pathophysiology of AHNP in rats and TMP has therapeutic effects probably by means of maintaning the balance of ET/PGI 2 rate,improving pancreatic microcirculation and then reducing serum amylase.

关 键 词：急性出血坏死性胰腺炎 内皮素 前列环素 川芎嗪 

分 类 号：R657.51[医药卫生—外科学]