调肝方药对束缚应激大鼠神经内分泌免疫功能的调节作用  

Regulation of ‘Tiao Gan Fang Yao’ on neuroendocrine-immuno-function of bandage-stressed rats

作　　者：严灿[1] 邓中炎[1] 王剑[1] 陈孝银[2] 

机构地区：[1]广州中医药大学基础医学院中医学基础教研室,广东广州510405 [2]暨南大学中医系,广东广州510632

出　　处：《中国病理生理杂志》2000年第6期560-562,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :探讨调肝方药对束缚应激大鼠神经内分泌免疫功能的调查作用。方法 :以束缚制动作为应激原复制应激反应大鼠模型 ,采用放射免疫法检测模型大鼠下丘脑 -垂体 -肾上腺轴功能 ,同时检测模型大鼠有关免疫功能的变化 ,并观察调肝方药的调节作用。结果 :束缚应激大鼠下丘脑 -垂体 -肾上腺轴 (HPAA)兴奋亢进 (P <0 0 1或P <0 0 5 ) ;脾淋巴细胞增殖反应降低 (P <0 0 1) ,腹腔巨噬细胞 (MΦ)释放H2 O2 功能下降 (P<0 0 1)。而调肝方药能抑制HPAA的兴奋性 ,提高大鼠的免疫机能。结论 :调肝方药对束缚应激所引起的神经内分泌免疫功能的紊乱具有一定的调节作用。AIM: To investigate the regulation of ‘Tiao Gan Fang Yao’(TGFY) on neuroendocrine-immuno-function of bandage-stressed rat . METHODS:The stressed rat model was made by bandage. RIA was adopted to measure the function of hypothalamus-pitutary-adrenal gland axis (HPAA) of stressed rat. Meanwhile, the immunity of stressed rat and the regulation of TGFY were observed.RESULTS:Bandage stress increased the contents of serum corticosterone(CORT), and ACTH, and hypothalamus corticotropin releasing hormone ( P <0 01 or 0 05), which suggested that the excitability of HPAA was enhanced. In addition, bandage stress reduced spleen lymphocyte proliferation ( P <0 01) and decreased H 2O 2 releasing from the macrophages significantly ( P <0 01). While TGFY could decrease HPAA excitability of bandage-stressed rat and strengthen its immunity.CONCLUSION:TGFY could regulate disorder of neuroendocrine-immuno-function of bandage-stressed rat.

关 键 词：应激 神经内分泌 调肝方药 免疫功能 大鼠 

分 类 号：R285.5[医药卫生—中药学]