抗精神病药物在维持治疗中对心电图影响的分析  

Electrocardiogram changes in psychiatric patients treated with antipsychotics

作　　者：孔令芳[1] 盛嘉玲 顾燕[1] 吕珍苏 张忆军[1] 刘焱[1] 

机构地区：[1]上海市民政第一精神卫生中心,上海201105

出　　处：《中国民康医学》2012年第23期2853-2855,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨抗精神病药物在慢性精神病患者维持治疗中对心电图的影响。方法:用自编的《住院精神病患者心电图异常调查表》对本院长期住院患者进行调查,对入组患者行十二导联心电图检查。根据检测结果对心电图异常发生率,服用和未服用抗精神病药物,药物的种类、剂量等因素进行统计分析。结果:本组患者599人中,其中心电异常人数229人,占38.23%。服用抗精神病药物者469人,有心电异常者187(占31.22%);未服抗精神病药物者130人,有心电异常者42人(占7.01%),两者差异有显著性(P值<0.05)。心电异常发生率最高的为:传导阻滞、窦性心动过速、T波改变。药物种类中以氯氮平组发生心电异常率最高70例(占40.70%),氯丙嗪组次之为86例(占39.27%),奋乃静组14例(占32.56%),利培酮组17例(占30.36%)。抗精神病药物剂量的大小与心电图异常间的差异无统计学意义(P值>0.05)。结论:抗精神病药物在精神病维持治疗中对心电图的影响是很常见的,与剂量的大小无关,利培酮和奋乃静对心电图影响小于氯氮平、氯丙嗪。Objective：To investigate the effects of antipsychotics on electrocardiogram （ ECG ） changes in psychiatric pa- tients. Methods ： The ECG of patients with antipsychotics were collected and the kinds of antipsychotics were compared. Results： A to- tal of 599 patients were evaluated. There were 229（ 38.23% ） patients with abnormal ECG, and conduction block was the most com- mon abnormal change, followed by tachycardia and T - wave changes. The abnormal ECG rates of clozapine, chloropromazine, chlor- perphenazine and risperidone were 40.70%, 39.27%, 32.56% and 30.36% , respectively. For all agents, there was no dose - re- sponse relationship for ECG changes. Conclusions： The ECG changes are common in patients with antipsychotics. The abnormal rate was lower in patients with risperidone and chlorperphenazine than others.

关 键 词：抗精神病药物 维持治疗 心电图异常 慢性精神病患者 

分 类 号：R971.4[医药卫生—药品]