利多卡因对缺血再灌注家兔心肌NF-κB和血浆ICAM-1 IL-8的影响  

Effects of lidocaine on myocardial NF-kappa B expression and plasma ICAM-1, IL-8 levels following myocardial ischemia reperfusion in rabbits

作　　者：王友[1] 王立赞[1] 王保生[1] 张效鹏[2] 胡新远[2] 

机构地区：[1]济宁医学院基础学院 [2]济宁医学院临床学院,山东济宁272067

出　　处：《济宁医学院学报》2012年第6期399-401,共3页Journal of Jining Medical University

基　　金：济宁市2009年科技局项目

摘　　要：目的研究利多卡因对家兔缺血再灌注心肌NF-κB表达及血浆ICAM-1、IL-8水平的影响。方法 18只家兔随机分为3组(每组6只),假手术组、缺血再灌注组和利多卡因组。测定各组家兔血浆ICAM-1、IL-8的水平,免疫组化方法观察心肌NF-κB表达情况。结果与缺血再灌注组比较,利多卡因后处理组再灌注后血浆ICAM-1和IL-8浓度明显低于缺血再灌注组(P<0.01),利多卡因可抑制心肌细胞NF-κB的表达。结论利多卡因可以抑制ICAM-1、IL-8的释放及NF-κB的表达,减轻家兔心肌缺血再灌注后炎性反应。Objective To investigate the effects of lidocaine on myocardial NF-κB expression and plasma ICAM-1,IL-8 levels following myocardial ischemia reperfusion in rabbits.Methods Eighteen rabbits were randomly divided into 3 groups（n= 6 each）：sham operation group,ischemic reperfusion group and lidocaine group.The levels of ICAM-1 and IL-8 in plasma were measured,and the degree of myocardial NF-κB expression was observed by immunohistochemical method.Results Compared with those of ischemic reperfusion group,ICAM-1 and IL-8 concentrations in lidocaine group were significantly lower（P0.01）.Lidocaine also reduced myocardial NF-κB expression.Conclusion Lidocaine could suppress plasma IL-8 and ICAM-1 levels and myocardial NF-κB expression,and alleviate inflammatory response induced by myocardial ischemia reperfusion.

关 键 词：利多卡因 心肌缺血再灌注损伤 ICAM-1 IL-8 NF-κB 

分 类 号：R542.2[医药卫生—心血管疾病]