胆道细菌感染的分布及药敏分析  

Distribution and Antibiotic Sensitivity of Bacteria Isolated from Patients with Biliary Tract Disorders

作　　者：刘适[1] 蔡瑞云[1] 李浩[1] 

机构地区：[1]湖南省人民医院检验科,湖南长沙410002

出　　处：《实用预防医学》2012年第12期1855-1857,共3页Practical Preventive Medicine

摘　　要：目的了解湖南省人民医院住院病人胆道感染细菌分布及其对目前常用抗生素的敏感性。方法对2011年1月1日-2012年6月30日245例胆道疾病患者胆汁培养阳性所检出的280株细菌及其药敏试验结果进行回顾性分析。结果检出革兰阴性细菌(G-菌)195株(69.6%),其中大肠杆菌78株(27.9%)、肺炎克雷伯菌39株(13.9%)和铜绿假单胞菌22株(7.9%)分列前三位;革兰阳性球菌(G+球菌)83株(29.6%),其中粪肠球菌29株(10.4%)、屎肠球菌13株(4.6%)和变异链球菌13株(4.6%)分列前三位;真菌(白色念珠菌)2株(0.7%)。G-菌主要对碳青霉烯类和氨基糖苷类药物敏感;G+球菌主要对糖肽类、硝基呋喃类和碳青霉烯类药物敏感。结论胆道细菌感染的菌种分布和药敏情况较前均发生了变化,应尽可能作胆汁培养指导临床合理用药,以减少耐药菌株的产生。Objective To investigate the distribution of bacteria isolated from inpatients with biliary tract disorders（BTD） and their sensitivities to common antibiotics.Methods We retrospectively analyzed drug sensitivity results of 280 bacterial strains isolated from the bile samples of the inpatients with BTD in the People＇s Hospital of Hunan Province from January 1,2011 to June 30,2012.Results Altogether 195 strains of Gram-negative bacteria were isolated from the bile samples,and the top three bacteria were Escherichia coli（27.9%,78/195）,Klebsiella pneumoniae（13.9%,39/195）,and Pseudomonas aeruginosa（7.9%,22/195）.83 strains of Gram-positive bacteria were isolated from the samples,and the top three bacteria were Enterococcus faecalis（10.4%,29/83）,Enterococcus faecium（4.6%,13/83）,Streptococcus mutans（4.6%,13/83）.And 2 strains of Candida albicans were isolated from the samples.The Gram-negative bacteria were mostly sensitive to carbapenems and amikacin,while the Gram-negative bacteria were mostly sensitive to glycopeptides,nitrofurans and carbapenems.Conclusions The bacterial distribution and their sensitivities to antibiotics in the inpatients with BTD have been changed.It is necessary to perform bile culture so as to guide reasonable clinical prescription and reduce the production of drug-resistant strains.

关 键 词：胆汁 细菌感染 药敏试验 

分 类 号：R379[医药卫生—病原生物学]