蒙古国人丙型肝炎患者HCV RNA检测及基因型的研究  

Detection and Genotyping of HCV RNA in Patients with Positive Anti-HCV Sera in Mongolia

作　　者：范公忍[1] 闻炜[1] 韩聚强[1] 胡学玲[1] 陈天宝[1] 曹建彪[1] 

机构地区：[1]北京军区总医院肝病治疗中心,北京100700

出　　处：《实用预防医学》2012年第12期1867-1869,共3页Practical Preventive Medicine

摘　　要：目的通过检测丙型肝炎病毒基因分型,探讨蒙古国抗-HCV阳性患者血清中HCV基因型流行株特征。方法采用基因芯片法对蒙古国183例抗-HCV阳性患者血清标本进行基因型检测,同时检测相关病毒学及肝功能生化指标,分析基因型分布特点和临床意义。结果 183例抗-HCV阳性患者中HCV RNA阳性134例(73.2%),其中基因1b型68例(50.7%),2a型59例(44.0%),并有少量的1a、3a、1b+2a和其它3例混合型。结论抗-HCV阳性并非HCV感染直接标志,蒙古国感染HCV患者的基因型以1b和2a型为主,比例基本相当;基因型在性别上人群分布差异无统计学意义。Objective To investigate the characteristics of the predominant epidemic genotype of the hepatitis C virus（HCV） in the patients with positive anti-HCV sera in Mongolia by HCV genotyping.Methods The genotype of HCV was identified by the gene-chip method in 183 Mongolian patients with positive anti-HCV sera and the virological and biochemical markers were detected.The characteristics of the genotype distribution and its clinical significance were analyzed.Results Totally,134 out of 183 anti-HCV positive sera（73.2%） were HCV RNA positive,including 68 cases（50.7%） of 1b genotype,59 cases（44.0%） of 2a genotype,a few cases of 1a,3a or 1b＋2a genotype,and 3 cases of mixed genotype.Conclusions Presence of anti-HCV is not the direct marker of hepatitis C infection.For the patients with positive anti-HCV sera in Mongolia,the major HCV genotypes are 1b and 2a,with almost equal ratios.The distribution of the genotypes does not differ between genders.

关 键 词：丙型肝炎病毒 基因型 蒙古国 

分 类 号：R512.63[医药卫生—内科学]