脉冲高强度聚焦超声参数设置与焦点声压的关系  

Relationship between Pulsed High Intensity Focused Ultrasound Parameter Setting and Focal Zone Acoustic Pressure

作　　者：史学豹[1,2] 赵纯亮[1,2] 宋柯[1,2] 王华[1,2] 

机构地区：[1]重庆医科大学生物医学工程学院,省部共建超声医学工程国家重点实验室,超声医学工程重庆市市级重点实验室,重庆400016 [2]超声医疗国家工程研究中心,重庆401121

出　　处：《世界科技研究与发展》2012年第6期1000-1003,1013,共5页World Sci-Tech R&D

基　　金：国家重大仪器专项(81127901)资助

摘　　要：脉冲高强度聚焦超声(PHIFU)对于提高治疗精确性和操作可控性具有潜在优势,PHIFU辐照过程中不同脉冲宽度及占空比的设置对焦点声压、空化现象出现后焦区声压的具体影响,成为目前迫切需要研究的问题。基于此,本文通过声光折射法测量了脉冲宽度为1 ms、10 ms、100 ms,脉冲间隔分别为100 ms、200 ms、500 ms、1000 ms时焦点声压随输入电压的变化数据,并与连续波辐照下的数据进行对比,结果显示在脉冲大于1 ms时,不同脉冲参数的焦点声压随电压变化规律一致,空化现象出现后焦点声压仍会继续升高并达到极值,空化气泡大量出现后焦区声压下降。Pulsed high intensity focused ultrasound have potential advantages in guaranteeing accuracy and operation controllability during ul- trasound treatment, it is an urgent problem to study the relationship between different pulse parameter setting and focal zone acoustic pressure, especially after cavitation bubbles appeared. Using audio-optical deflection method, this paper proposes the measurements results of focal zone acoustic pressure of different pulse widths and intervals setting under increasing input voltages, and meanwhile compare the results with CW insonation. It is shown that when pulse width＇ longer than 1 ms,the regularity of focal zone acoustic pressure changing with input voltage of different pulse parameter settings in accord with each other. After cavitation bubbles appeared, the focal zone acoustic pressure continue rising with the increasing input voltage and reaches a maximum value, when vast cavitation bubbles appeared, the focal zone acoustic pressure decreases.

关 键 词：脉冲高强度聚焦超声 脉冲参数 焦点声压 声光折射法 

分 类 号：O426.9[理学—声学]