肠道微生态与定植抗力  

Gut microbial ecosystem and colonization resistance

作　　者：沈定树[1] 陈素云[1] 

机构地区：[1]浙江省台州医院检验科,浙江台州317000

出　　处：《中国微生态学杂志》2012年第12期1150-1152,共3页Chinese Journal of Microecology

摘　　要：分子生物学技术的研究表明,肠道微生物群落无论是亚种或菌株水平有极大的多样性,宿主与微生物之间相互选择,构成了一个相对稳定的超级生物体。由于微生物群落是由多种细胞系组成,细胞间或细胞与宿主之间有信息交流能力,在宿主的营养、免疫和代谢中有重作用。肠道微生物定植抗力机制还未完全清楚,但至少有三种机制认为:(1)正常肠道微生物的代谢物可直接抑制致病菌的生长;(2)正常肠道微生物的生长可以竟争性的消耗掉致病菌所需的营养物质;(3)正常肠道微生物可诱导或剌激宿主的先天和后于的免疫反应。Recently developed molecular biology approaches indicate that gut microbiota is dominated by relatively few divisions that are highly diversity at the strain/subspecies level.The microbiota and host select each other to form a superorganism.As gut microbiota is made up by many kinds cell line,there is capability of message communication.It is an important effect in nutrient,immunity and metabolism of host.The mechanistic basis of CR is incompletely defined.At least three mechanisms seem to contribute：（1） direct inhibition of pathogen growth by microbiota-derived substances,（2） nutrient depletion by microbiota growth,and（3） microbiota-induced stimulation of innate and adaptive immune responses.

关 键 词：肠道微生态 多样性 定植抗力 

分 类 号：R378.992[医药卫生—病原生物学]