匹伐他汀钙对高脂血症患者高敏C反应蛋白和血管内皮功能的影响  被引量:1

The influence of pitavastatin on the hypersensitivity C reactive protein and artery endothelial function of patients with hyperlipidemia

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作  者:张永红[1] 乔钦增[1] 曹桂山 侯津杰[3] 

机构地区:[1]河北省民政总医院,054000 [2]河北省邢台县黄寺中心卫生院 [3]邢台医学高等专科学校

出  处:《山西医药杂志(下半月)》2012年第12期1236-1238,共3页Shanxi Medical Journal

摘  要:目的研究匹伐他汀钙对高脂血症患者高敏C反应蛋白和血管内皮功能的影响。方法选取本院心内科住院的高血脂患者,随机分为对照组和治疗组,对照组仅给予低脂饮食。治疗组在低脂饮食的基础上,另服用匹伐他汀钙分散片,连续口服8周。2组患者均在治疗前和治疗第8周末测定各项指标。结果治疗组在治疗8周后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均明显下降(P<0.01),治疗组匹伐他汀钙治疗8周后,血清C反应蛋白(CRP)、内皮素(ET)水平较治疗前明显降低(P<0.05);与对照组治疗后比较明显降低(P<0.05)。结论匹伐他汀钙能明显降低血脂,同时降低血浆CRP水平,改善血管内皮功能作用明显。Objective To study the influence of pitavastatin on the hypersensitive C reactive protein and artery endothelial function of patients with hyperlipidemia.Methods The hyperlipidemia patients were randomly divided into two group,and the control group was only given a low-fat diet.In the treatment group a low-fat diat was given,together with continuous oral administration of pitavastatin dispersible tablets,for 8 weeks.The TC,LDL-C,ET of two groups were determined before treatment and serum CRP,ET levels eighth week.Results TC,LDL-C of the treatment group after 8 week were obviously decreased(P0.01),the end of the treatment group in after 8 week were significantly decreased compared with those before treatment(P0.05);and were significantly reduced compared with the control group after treatment(P0.05).Conclusion The pitavastatin can significantly reduce the blood lipid and plasma CRP levels,obviously improve artery endothelial function.

关 键 词:高脂血症 C反应蛋白质 内皮 血管 匹伐他汀 

分 类 号:R541.4[医药卫生—心血管疾病]

 

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