血液灌流和纳洛酮抢救安眠药中毒的疗效观察  

Curative effect observation of blood perfusion and naloxone in the treatment of hypnotic poisoning

作　　者：霍秋玉[1] 

机构地区：[1]南京医科大学附属南京明基医院急诊科,江苏南京210019

出　　处：《实用临床医药杂志》2012年第21期56-58,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11220149)

摘　　要：目的探讨血液灌流和纳洛酮抢救安眠药中毒的临床疗效及其临床应用价值。方法回顾性分析本院于2008年1月—2012年5月收治的32例安眠药重度中毒患者,随机分为2组,治疗组接受血液灌流和纳洛酮治疗,对照组接受常规治疗。观察并比较2组患者治疗前和治疗1周后的血压、心率、血清的pH、血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、苏醒时间、血浆中的毒物浓度、各种并发症等指标。结果 2组患者在治疗后病情得到显著好转,无1例死亡,但治疗组的疗效显著好于对照组,治疗组患者完全苏醒时间、住院时间和血浆药物浓度降至正常范围内的时间显著低于对照组。结论血液灌流联合纳洛酮联合抢救安眠药中毒,明显提高安眠药中毒治愈率,减少并发症,不良反应少,值得在临床推广。Objective To discuss the curative effect of blood perfusion and naloxone in the treatment of hypnotic poisoning. Methods Thirty - two patients with hypnotic poisoning from January 2008 to May 2012 in our hospital were analyzed retrospectively and were randomly divided into two groups. The treatment group received blood perfusion and naloxone treatment, while the control group received routine treatment. The indices of blood pressure, heart rate, serum pH, PaO2, PaCO2, recovery time, the toxicant concentration in plasma, various complications in the two groups before treatment and after a week＇ s treatment were observed and analyzed. Results The conditions of two groups were improved dramatically after treatment, no deaths occurred, but the curative effect of the treatment group was significantly better than that of the control group. The indices of total wake time, hospitalization time and time of plasma drug concentrations within the normal range in the treatment group were significantly lower than those in the control group. Conclusion Hemoperfusion combined with naloxone in the treatment of patients with hypnotic poisoning can significantly improve the cure rate, decrease the complications and it have fewer adverse reactions and it is worthy of clinical application.

关 键 词：血液灌流 纳洛酮 安眠药中毒 

分 类 号：R595.4[医药卫生—内科学]