多孔Ti3Zr2Sn3Mo25Nb钛合金表面活性次级微孔涂层的制备及其成骨性能  

Preparation and Osteogenesis of Active Secondary Microporous on the Porous Ti3Zr2Sn3Mo25Nb Titanium Alloy

作　　者：余森[1] 于振涛[1] 韩建业[1] 张明华[2] 牛金龙[1] 刘春潮[1] 

机构地区：[1]西北有色金属研究院,西安710016 [2]第四军医大学唐都医院全军骨肿瘤研究所,西安710038

出　　处：《中国表面工程》2012年第6期101-106,共6页China Surface Engineering

基　　金：国家自然科学基金"中澳科技合作特别基金"(31011120049);国家自然科学基金(31100693/C100302);陕西省"13115"科技创新工程重大科技专项(2010ZDKG-96)

摘　　要：为提高多孔医用钛合金的生物活性,以实现快速骨整合,首先利用微弧氧化法在多孔Ti3Zr2Sn3Mo25Nb(TLM)合金表面制备出含Ca、P的次级微孔涂层,并通过水热处理在此涂层表面生成羟基磷灰石。通过XRD、SEM和EDS分析了活性次级微孔涂层的相组成、微观形貌和元素特征,通过接触角测试试验对比研究了TLM合金表面改性前后的亲水性变化,并进一步通过动物试验检测了表面活性次级微孔涂层改性后多孔TLM合金的成骨性能。结果表明,微弧氧化处理可在多孔TLM表面形成规整的含Ca、P相的次级微孔层,水热处理后次级微孔层的亲水性增强,且具有良好的成骨诱导性能。Porous biomedical titanium alloys are widely used in clinical applications, including porous coated orthopedic and dental implants. However, they do not have bioactivity as bone-substitute implant materials. The present work was undertaken to improve the bioactivity （especially osteoinduction） of the porous Ti3Zr2Sn3Mo25Nb （TLM） alloy. The secondary microporous coatings were first prepared by the micro-arc oxidation method on the surface of porous TLM alloy in the electrolyte containing Ca and P, and then hydroxyapatite was fabricated on the microporous coatings by hydrothermal synthesized treatment. The phase composition, surface micro-topography and elemental characteristics of the active microporous coatings were investigated by XRD, SEM and EDS. The hydrophilicity was evaluated by the contact angle test. The osteoin- duction was evaluated by implantation in hard tissue. Results show that a HA-incorporated, porous Ti02 layer is produced successfully on the porous TLM alloy, and the TLM alloy coated with an active secondary micro- porous coatings exhibits better hydrophilicity, good osteoinduction in hard tissue, which can promote the bone formation.

关 键 词：多孔钛合金 成骨活性 次级微孔 Ti3Zr2Sn3Mo25Nb合金 生物活性 

分 类 号：TG174.46[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]