中药卷柏抗肿瘤作用及新型炔酚类化合物Selaginellin的研究进展  

Research Progress of Selaginellin and the Anti-tumor Activity of Selaginella

作　　者：曾庆海[1] 涂超[2] 范凡[3] 陈尧磊[4] 殷俊[3] 曾勇[5] 

机构地区：[1]中南大学湘雅三医院,湖南长沙410013 [2]中南大学湘雅二医院,湖南长沙410013 [3]中南大学湘雅医院,湖南长沙410008 [4]重钢总医院脑外科,重庆大渡口400081 [5]湖南省肿瘤医院药学部,湖南长沙410013

出　　处：《肿瘤药学》2012年第6期402-406,共5页Anti-Tumor Pharmacy

基　　金：国家自然科学基金项目资助(81201730);湖南省卫生厅科技计划项目资助(132011-091)

摘　　要：卷柏属植物资源丰富,药理作用广泛,近年来国内外在卷柏属药用植物的资源、活性成分、药理作用等方面有很多新发现和研究。特别是卷柏属植物的抗肿瘤作用引起了广大学者的关注,目前多认为卷柏属植物中的双黄酮类是其发挥抗肿瘤作用的主要物质。细胞毒作用,诱导细胞凋亡,阻滞肿瘤细胞的侵袭、转移,是双黄酮类发挥抗肿瘤作用的主要机制。卷柏属新型炔酚类化合物Selaginellin是近几年分离得到的新型碳骨架化合物,除了具有抗氧化作用外,最近发现其能通过发挥细胞毒作用,从而起到抗肿瘤的作用。本文针对近年来对卷柏属植物的抗肿瘤作用及其机制的研究概况以及对Selaginellin的研究历程、抗肿瘤作用等研究概况进行综述。Plants in Selaginella Genus are in abundance on the earth, and can be applied in many medical situations. Recently there are a lot of new discoveries and researches being done in exploring the resources, active components, and phamlaceutical effects of Selaginella nationally and internationally. During all these discoveries, the anti-tumor activity of Selaginella attracts more and more scholars, and Bisflavones in Selaginellin are considered the chief effective ingredient. Cytotoxicity, induction of apoptosis, blocking the invasion of tumor cells, transfer are the main mechanisms of pairs of flavonoids which plays anti-tumor effect. Selaginellin isolated in recent years was a new type of carbon skeleton of com- pounds, in addition to its antioxidant activity, recently its cytotoxicity have been found playing the role of anti-tumor. This article provides a general review for the research progress and phamlaceutical effects of Selaginellin, anti-tumor activity of Selaginella, and its mechanisms in the last few years.

关 键 词：卷柏属 抗肿瘤 双黄酮类 新型炔酚类化合物 

分 类 号：R284[医药卫生—中药学]