薄荷醇影响地西泮鼻腔吸收的药效学  

The effect of l-menthol on the intranasal absorption to diazepam

作　　者：盛平[1] 张瑞涛[2] 王晖[3] 聂昊[3] 傅晓华[1] 

机构地区：[1]广东药学院附属第二医院广州新海医院,广东广州510300 [2]三峡大学,湖北宜昌443002 [3]广东药学院中药学院,广东广州510006

出　　处：《中国医院药学杂志》2012年第24期1957-1960,共4页Chinese Journal of Hospital Pharmacy

基　　金：广东省科技计划项目(编号:2011B080702004)

摘　　要：目的:研究鼻腔给药的地西泮以及与薄荷醇配伍后的中枢抑制作用特点。方法:以鼻腔给药的方式建立小鼠模型,对鼻腔给药的地西泮及其与薄荷醇伍用后的镇静催眠及抗惊厥的中枢抑制作用效果进行评价。结果:与溶剂对照组相比,经鼻腔途径给药的地西泮能抑制电刺激和士的宁引起的惊厥发作并且增强戊巴比妥钠的镇静催眠作用,并与其同剂量腹腔给药的药效相近;薄荷醇在一定程度上能增强鼻腔给药的地西泮的药效。结论:地西泮经鼻腔给药能发挥镇静催眠和抗惊厥作用,药效与给药浓度成剂量-效应关系;鼻腔给予同剂量的地西泮与腹腔给药的药效相近;伍用薄荷醇后,地西泮的药效在一定程度上增强。OBJECTIVE To study the effect of diazepam or combined with 1 menthol on the central inhibitory action by in tranasal administration. METHODS MES acute seizure model, strychnine seizure threshold test and synergia effect test of diazepam and Barbital drugs in mice were performed to evaluate the effects of l-menthol on Intranasal diazepam＇s hypnotic and anti- convulsive actions. RESULTS Compared with the control group, intranasal diazepam can inhibit convulsion induced by electri- cal stimulation or strychnine. And it enhances pentobarbital sleeping effects. The results o{ intranasal diazepam are similar to the results of gavage administration. In additional, l- menthol can strengthen intranasal diazepam＇s efficacy a certain extent. CONCLUSION Diazepam via intranasal administration could take sedative-hypnotic action and control the epileptic seizure with a dose-response relationship and the effect was similar to the results o~ gavage administration. /-menthol could strengthened when combined with 1-menthol.

关 键 词：地西泮 薄荷醇 鼻腔给药 中枢抑制 

分 类 号：R965[医药卫生—药理学]