骨科膝关节置换患者术后应用地佐辛注射液镇痛的疗效分析  

Observation on the curative effect of orthopedic knee replacement patients after application of dezocine analgesic

作　　者：宋建治[1] 肖少雄[1] 徐礼森[1] 

机构地区：[1]武汉市第一医院骨科,湖北武汉430022

出　　处：《中国医院药学杂志》2012年第24期1989-1991,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察地佐辛用于骨科膝关节置换术后的镇痛疗效及安全性。方法:骨科膝关节置换患者100例,双盲随机数字抽样法分为治疗组(50例)和对照组(50例)。治疗组患者术后应用地佐辛静脉镇痛,对照组患者术后应用芬太尼静脉镇痛。采用视觉模拟评分(VAS)、镇静评分(Ramsay)评分标准,比较2组患者的术后镇痛效果和不良反应发生率。结果:治疗组与对照组术后在VAS评分和Ramsay评分方面比较后无统计学差异(P>0.05)。在不良反应发生率方面,治疗组明显低于对照组,2组间比较后有统计学差异(P<0.05)。结论:骨科膝关节置换术后应用地佐辛具有良好的镇痛效果,同时不良反应明显减少,值得膝关节置换患者术后镇痛临床推广。ObJECTIVE To observe the efficacy and safety of dezocine used in orthopedic knee replacement patients for post- operative analgesia. METHODS Orthopedic knee replacement in 100 patients were divided into the following two groups（n = 51））, the treatment group（in 50 cases） and the control group（in 50 cases）. The treatment group patients using dezocine intrave- nous analgesia while the control group patients using intravenous analgesia with fentanyl. Comparing the two groups of patients with postoperative analgesia and the incidence of adverse reactions in choosing the visual analogue scale（VAS）and the sedation score（Ramsay）evaluation standards. RESULTS The treatment group and the control group after operation in VAS score and Ramsay score had no significant difference in statistic （P〉0. 05）. The incidence rate of adverse reaction in treatment group was significantly lower than that in the control group. Compared with each other, there was significant difference in statistic （P〈 0. 05）. CONCLUSION Orthopedic knee replacement after using dezocine had good analgesic effect,the side effects were signifi- cantly reduced. IT＇s worthy of clinical promotion after the knee replacement in patients with postoperative analgesia.

关 键 词：地佐辛 芬太尼 术后镇痛 膝关节置换术 

分 类 号：R971.9[医药卫生—药品]