动物性成熟启动基因网络和神经内分泌调节研究进展  

Research Progress on Gene Networks and the Neuroendocrine Regulation of Animal Puberty Onset

作　　者：韩威[1,2] 李慧芳[1] 朱云芬[1] 宋迟[1] 陶志云[1] 

机构地区：[1]中国农业科学院家禽研究所,江苏扬州225125 [2]南京农业大学,江苏南京210095

出　　处：《家畜生态学报》2012年第6期5-10,共6页Journal of Domestic Animal Ecology

基　　金：国家自然科学基金(31201799);江苏省家禽科学研究所青年基金项目(JQ201006);现代农业产业技术体系建设专项资金;国家863计划项目(2011AA100305)

摘　　要：动物性成熟启动是一个复杂的生物学过程,其决定性事件是下丘脑GnRH脉冲式释放增加。GnRH脉冲式释放增加是由跨突触改变和神经胶质输入两个方面共同引起的,其中,跨突触改变由谷氨酸能神经元、Kisspeptin神经元、γ-氨基丁酸能神经元、阿片能神经元及RFRP神经元提供,而神经胶质输入主要由生长因子家族提供。诸多功能基因参与了性成熟启动过程,组成了复杂的基因调控网络,这些基因并不是按照严格的等级顺序排列,而是在功能上有所重叠。转录调节因子的抑制性作用使得性成熟启动不会提早发生。论文还介绍了表观机制在性成熟启动调控中的重要作用。Puberty onset of animals is a complex biological process, the increase in pulsatile release of gonadotrophin releasing hormone （GnRH） from the hypothalamus is the determined event. This increase of GnRH secretion is brought by changes in transsynaptic provided by glutamatergic, Kisspeptin, GABAergic and opiatergic neurons, and glial inputs provided mainly by growth factors. Many genes are involved in the initiation of puberty, forming complex gene networks. These genes are arranged in overlap- ping networks, not organized in a strict hierarchical fashion. The repression by transcriptional regulators makes the puberty onset impossible to occur earlier. The paper also introduced that epigenetic mechanisms play an important role in neuroendocrine control of puberty.

关 键 词：性成熟启动 基因网络 转录抑制 表观调控 

分 类 号：S811.6[农业科学—畜牧学]