持续性非卧床腹膜透析患者继发性甲状旁腺功能亢进相关因素分析  

Analysis of associated factors in secondary hyperparathyroidism of continuous ambulatory peritoneal dialysis patients

作　　者：周红梅[1] 徐庆东[1] 郑智华[1] 阳晓[1] 余学清[1] 

机构地区：[1]中山大学附属第一医院肾内科卫生部肾脏病临床研究重点实验室,广州510080

出　　处：《中华肾脏病杂志》2012年第12期933-936,共4页Chinese Journal of Nephrology

摘　　要：目的探讨持续性非卧床腹膜透析（CAPD）患者继发性甲状旁腺功能亢进（SHPT）的患病率及相关因素。方法分析2011年7月至2012年1月在本院腹膜透析中心规律随访的CAPD患者数据库资料。所有患者根据全段甲状旁腺激素（iPTH）分为甲状旁腺功能亢进组及甲状旁腺功能非亢进组。通过Logistic回归分析SHPT的相关影响因素。结果共纳入639例患者，SHPT的患病率为46．95％。Logistic多因素回归分析结果显示，低血红蛋白、低血钙、高血磷、高碱性磷酸酶、高血肌酐、高标准化蛋白分解代谢率（nPCR）及低钙透析液是SHPT的独立影响因素。结论CAPD患者中SHPT患病率较高，钙磷代谢异常、高蛋白饮食、肾性贫血及低钙透析液是影响SHPT发生的独立因素。Objective To study the prevalence and associated factors of secondary hyperparathyroidism （SHPT） in continuous ambulatory peritoneal dialysis （CAPD） patients. Methods A cross-section study was performed. A total of 639 eligible participants undergoing CAPD treatment more than three months in our peritoneal dialysis center from July 2011 to January 2012 were recruited in the study. All the patients were divided into SHPT group and non- SHPT group according to the intact parathyroid hormone （iPTH） level, and the associated factors of SHirr were investigated through Logistic regression analysis. Results The prevalence of SHPT was 46.95% （300/639）. Logistic regression analysis demonstrated that lower hemoglobin, hypocalcemia, hyperphosphatemia, higher alkaline phosphatase, higher Scr, higher nPCR and low calcium dialysate were independent influencing factors of SHPT. Conclusions The prevalence of SHPT is quite high in CAPD patients. Abnormal calcium-phosphorus metabolism, renal anemia, high protein diet and low calium dialysate may affect the SHPT.

关 键 词：腹膜透析 甲状旁腺功能亢进症 继发性 流行病学 回归分析 

分 类 号：R692.5[医药卫生—泌尿科学]