丹参注射液治疗出血性中风急性期临床疗效的系统评价  

The Systematic Review of Danshen injection for acute hemorrhagic stroke

作　　者：马丽虹[1] 田财军[1] 师冉[1] 李可建[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中国中医急症》2012年第12期1960-1962,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然基金委资助课题(30801458)

摘　　要：目的系统评价丹参注射液治疗出血性中风急性期的临床疗效及安全性。方法搜集丹参注射液治疗出血性中风急性期随机对照试验文献,筛选合格研究,应用Jadad评分法进行质量评价,运用异质性检验、Meta分析、漏斗图分析等方法统计相关数据。结果 7项研究符合纳入标准,Meta分析结果显示,总有效率比较的合并RR(99%CI)为1.30(1.15,1.47),需治疗的病例数(99%CI)为4.55(3.23,8.33);神经功能缺损评分比较、脑出血量变化比较的WMD(99%CI)分别为-3.67(-4.50,-2.83)、-3.05(-4.70,-1.40)。结论现有临床证据提示丹参注射液有益于改善出血性中风急性期脑出血及神经功能缺损情况,且安全性较好。Objective： To evaluate efficacy and safety of danshen injection for acute hemorrhagic stroke.Methods： Randomized controlled trails（RCTs） of danshen injection for acute hemorrhagic stroke were identified,eligible studies were included,the methodological quality of inclusive trails was assessed by Jadad scale.Heterogeneity test,Meta-analysis,funnel plot analysis and sensitivity analysis were used to analyse data.Results： 7 RCTs were included,Meta-analysis indicated that relative risk of overall effective rate is 1.30[99%CI（1.15,1.47）],NNT（99%CI） is4.55（3.23,8.33）;WMD（99%CI） of Neural function defect score is-3.67（-4.50,-2.83）,WMD（99%CI） of cerebral hemorrhage is-3.05（-4.70,-1.40）.Conclusion： This systematic review shows that danshen injection is effective for acute hemorrhagic stroke and that the safety is very good.

关 键 词：丹参注射液 急性期出血性中风 随机对照试验 系统评价 

分 类 号：R255.2[医药卫生—中医内科学]