氧化震颤素对AVP引起低温的影响与环境温度的关系  

Effects of Oxotremorine on AVP-induced Hypothermia and Its Relationship with Ambient Temperature

作　　者：沈字玲[1] 杨永录[1] 王念[1] 孟立[1] 唐瑜[1] 

机构地区：[1]成都医学院生理教研室,体温调节实验室,610083

出　　处：《医学研究杂志》2012年第12期89-92,共4页Journal of Medical Research

基　　金：四川省教育厅基金资助项目(11ZA229);成都医学院资助项目(CYZ07-009)

摘　　要：目的观察胆碱能激动剂氧化震颤素对精氨酸加压素(AVP)引起大鼠低温反应的影响及其与环境温度变化的关系。方法用无线遥控测温技术连续同步记录成年雌性SD大鼠体核温度(Tc)和活动变化。在中性(25℃)、热(30℃)和冷(18℃)环境中,分别观察AVP(10μg/kg)和氧化震颤素(0.25mg/kg)对大鼠Tc和活动的影响。结果分别给置于25℃、30℃和18℃环境中的大鼠注射AVP或氧化震颤素后,均能引起大鼠Tc迅速降低,但18℃环境中Tc的降低比25℃和30℃更明显。3种环境温度中,氧化震颤素均能使AVP引起的低温反应更明显,并持续更长时间。但18℃环境中,氧化震颤素增强AVP引起低温反应的作用明显大于25℃和30℃。结论①AVP引起的低温可能与体温调定点下移有关,因为在冷环境中AVP引起的低温反应更明显;②氧化震颤素能够增强AVP引起的大鼠低温反应,此作用在冷环境中最明显,提示氧化震颤素可能通过影响体温调定点参与AVP引起的低温反应。Objective To investigate the effects of cholinergic agonists oxotremorine on arginine vasopressin （AVP） - induced hy- pothermia in rats and its relationship with ambient temperature changes. Methods Core temperature （Tc） and motor activities were mo- nitored in undisturbed female SD rats using radiotelemetry. Effects of AVP （10μg/kg） and oxotremorine （0.25mg/kg） on Tc and motor activities were observed at ambient temperature of neutral （25℃）, warm （30℃） and cold （ 18℃ ）, respectively. Results Administra- tion of AVP or oxotremorine alone caused a significant drop in Tc at ambient temperatures of 25℃ , 30℃ and 18℃ , respectively. But at ambient temperature of 18℃ , Tc was lower than at 25℃ and 30℃. AVP - induced hypothermia was augmented by oxotremorine and last- ing a longer time at different ambient temperatures. Furthermore, at ambient temperature of 18℃ , the effect of oxotremorine to augment AVP - induced hypothermia was more obvious than at 30℃ and 25℃. Conclusion The hypothermic effects of AVP may be related with the set - point temperature reduction, because AVP - induced hypothermia was greatest at cold ambient temperature; The effect of oxo- tremorine to augment AVP- induced hypothermia was greatest at cold ambient temperature,which indicated that oxotremorine appeared to participate in AVP - induced hypothermia by affecting set point temperature.

关 键 词：精氨酸加压素 氧化震颤素 低温 环境温度 

分 类 号：R971[医药卫生—药品]